N-phenylalkyl-substituted tropane analogs of boat conformation with high selectivity for the dopamine versus serotonin transporter

K. R.C. Prakash; Amir P. Tamiz; Gian Luca Araldi; Mei Zhang; Kenneth M. Johnson; Alan P. Kozikowski

doi:10.1016/S0960-894X(99)00607-1

N-phenylalkyl-substituted tropane analogs of boat conformation with high selectivity for the dopamine versus serotonin transporter

K. R.C. Prakash, Amir P. Tamiz, Gian Luca Araldi, Mei Zhang, Kenneth M. Johnson, Alan P. Kozikowski

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

A series of N-phenylalkyl-substituted tropane analogs of boat conformation was synthesized, and these tropanes were evaluated for their ability to inhibit high affinity uptake of dopamine (DA) and serotonin (5HT) into striatal nerve endings (synaptosomes). Some of these compounds exhibit high affinity for the DA transporter with a 5-HT/DA transporter selectivity ratio of >50.

Original language	English (US)
Pages (from-to)	3325-3328
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	9
Issue number	23
DOIs	https://doi.org/10.1016/S0960-894X(99)00607-1
State	Published - Dec 6 1999
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(99)00607-1

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abstract = "A series of N-phenylalkyl-substituted tropane analogs of boat conformation was synthesized, and these tropanes were evaluated for their ability to inhibit high affinity uptake of dopamine (DA) and serotonin (5HT) into striatal nerve endings (synaptosomes). Some of these compounds exhibit high affinity for the DA transporter with a 5-HT/DA transporter selectivity ratio of >50.",

author = "Prakash, {K. R.C.} and Tamiz, {Amir P.} and Araldi, {Gian Luca} and Mei Zhang and Johnson, {Kenneth M.} and Kozikowski, {Alan P.}",

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T1 - N-phenylalkyl-substituted tropane analogs of boat conformation with high selectivity for the dopamine versus serotonin transporter

AU - Prakash, K. R.C.

AU - Tamiz, Amir P.

AU - Araldi, Gian Luca

AU - Zhang, Mei

AU - Johnson, Kenneth M.

AU - Kozikowski, Alan P.

PY - 1999/12/6

Y1 - 1999/12/6

N2 - A series of N-phenylalkyl-substituted tropane analogs of boat conformation was synthesized, and these tropanes were evaluated for their ability to inhibit high affinity uptake of dopamine (DA) and serotonin (5HT) into striatal nerve endings (synaptosomes). Some of these compounds exhibit high affinity for the DA transporter with a 5-HT/DA transporter selectivity ratio of >50.

AB - A series of N-phenylalkyl-substituted tropane analogs of boat conformation was synthesized, and these tropanes were evaluated for their ability to inhibit high affinity uptake of dopamine (DA) and serotonin (5HT) into striatal nerve endings (synaptosomes). Some of these compounds exhibit high affinity for the DA transporter with a 5-HT/DA transporter selectivity ratio of >50.

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DO - 10.1016/S0960-894X(99)00607-1

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 23

ER -

N-phenylalkyl-substituted tropane analogs of boat conformation with high selectivity for the dopamine versus serotonin transporter

Abstract

ASJC Scopus subject areas

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