Mutagenic cholesterol preparations

Leland L. Smith, Vera B. Smart, G. A.S. Ansari

Research output: Contribution to journalArticlepeer-review

74 Scopus citations


Naturally air-aged commercial samples of USP or reagent-grade cholesterol contain components which are mutagenic towards Salmonella typhimurium strains TA1537, TA1538 and TA98. These mutagenic components are associated with the polar cholesterol autoxidation products, but identify of the mutagenic components has not been achieved. Pure crystalline nonmutagenic cholesterol free from autoxidation products becomes mutagenic towards these strains upon heating at 70° in air or following exposure to 60Co γ-radiation.

Original languageEnglish (US)
Pages (from-to)23-30
Number of pages8
JournalMutation Research/Genetic Toxicology
Issue number1
StatePublished - Sep 1979

ASJC Scopus subject areas

  • Toxicology
  • Genetics


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