Mutagenic cholesterol preparations

Leland L. Smith; Vera B. Smart; G. A.S. Ansari

doi:10.1016/0165-1218(79)90074-0

Mutagenic cholesterol preparations

Leland L. Smith, Vera B. Smart, G. A.S. Ansari

Center for Addiction Sciences and Therapeutics

Research output: Contribution to journal › Article › peer-review

74 Scopus citations

Abstract

Naturally air-aged commercial samples of USP or reagent-grade cholesterol contain components which are mutagenic towards Salmonella typhimurium strains TA1537, TA1538 and TA98. These mutagenic components are associated with the polar cholesterol autoxidation products, but identify of the mutagenic components has not been achieved. Pure crystalline nonmutagenic cholesterol free from autoxidation products becomes mutagenic towards these strains upon heating at 70° in air or following exposure to ⁶⁰Co γ-radiation.

Original language	English (US)
Pages (from-to)	23-30
Number of pages	8
Journal	Mutation Research/Genetic Toxicology
Volume	68
Issue number	1
DOIs	https://doi.org/10.1016/0165-1218(79)90074-0
State	Published - Sep 1979

ASJC Scopus subject areas

Toxicology
Genetics

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abstract = "Naturally air-aged commercial samples of USP or reagent-grade cholesterol contain components which are mutagenic towards Salmonella typhimurium strains TA1537, TA1538 and TA98. These mutagenic components are associated with the polar cholesterol autoxidation products, but identify of the mutagenic components has not been achieved. Pure crystalline nonmutagenic cholesterol free from autoxidation products becomes mutagenic towards these strains upon heating at 70° in air or following exposure to 60Co γ-radiation.",

author = "Smith, {Leland L.} and Smart, {Vera B.} and Ansari, {G. A.S.}",

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AU - Smart, Vera B.

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AB - Naturally air-aged commercial samples of USP or reagent-grade cholesterol contain components which are mutagenic towards Salmonella typhimurium strains TA1537, TA1538 and TA98. These mutagenic components are associated with the polar cholesterol autoxidation products, but identify of the mutagenic components has not been achieved. Pure crystalline nonmutagenic cholesterol free from autoxidation products becomes mutagenic towards these strains upon heating at 70° in air or following exposure to 60Co γ-radiation.

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Mutagenic cholesterol preparations

Abstract

ASJC Scopus subject areas

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