Multisite biologic tissue SARS-CoV-2 PCR testing in kidney transplantation from a COVID-positive donor

Jared R. Zhang; Michael Kueht; Alfred Lea; Heather L. Stevenson; Joseph Gosnell; Ping Ren; Marisa C. Nielsen; Aaron Miller; Muhammad Mujtaba; Jeffrey Fair

doi:10.1093/jscr/rjac314

Multisite biologic tissue SARS-CoV-2 PCR testing in kidney transplantation from a COVID-positive donor

Jared R. Zhang, Michael Kueht, Alfred Lea, Heather L. Stevenson, Joseph Gosnell, Ping Ren, Marisa C. Nielsen, Aaron Miller, Muhammad Mujtaba, Jeffrey Fair

Research output: Contribution to journal › Article › peer-review

Abstract

With a high community transmission rate, SARS-CoV-2 has profoundly exacerbated the shortage of organs. Although the risk of donor-recipient transmission of SARS-CoV-2 is anecdotally low, an organ-specific infection analysis of procured organs from SARS-CoV-2 positive donors has yet to be established. Using a combination of clinically available and research-only polymerase chain reaction methods, organ preservation fluid and renal parenchymal tissues were tested for SARS-CoV-2 from the kidney of a SARS-CoV-2-positive donor prior to transplantation. The recipient has remained SARS-CoV-2 negative and clinically well, with excellent graft function 120 days post-transplantation.

Original language	English (US)
Article number	rjac314
Journal	Journal of Surgical Case Reports
Volume	2022
Issue number	7
DOIs	https://doi.org/10.1093/jscr/rjac314
State	Published - Jul 1 2022

ASJC Scopus subject areas

Surgery

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title = "Multisite biologic tissue SARS-CoV-2 PCR testing in kidney transplantation from a COVID-positive donor",

abstract = "With a high community transmission rate, SARS-CoV-2 has profoundly exacerbated the shortage of organs. Although the risk of donor-recipient transmission of SARS-CoV-2 is anecdotally low, an organ-specific infection analysis of procured organs from SARS-CoV-2 positive donors has yet to be established. Using a combination of clinically available and research-only polymerase chain reaction methods, organ preservation fluid and renal parenchymal tissues were tested for SARS-CoV-2 from the kidney of a SARS-CoV-2-positive donor prior to transplantation. The recipient has remained SARS-CoV-2 negative and clinically well, with excellent graft function 120 days post-transplantation.",

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AU - Zhang, Jared R.

AU - Kueht, Michael

AU - Lea, Alfred

AU - Stevenson, Heather L.

AU - Gosnell, Joseph

AU - Ren, Ping

AU - Nielsen, Marisa C.

AU - Miller, Aaron

AU - Mujtaba, Muhammad

AU - Fair, Jeffrey

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AB - With a high community transmission rate, SARS-CoV-2 has profoundly exacerbated the shortage of organs. Although the risk of donor-recipient transmission of SARS-CoV-2 is anecdotally low, an organ-specific infection analysis of procured organs from SARS-CoV-2 positive donors has yet to be established. Using a combination of clinically available and research-only polymerase chain reaction methods, organ preservation fluid and renal parenchymal tissues were tested for SARS-CoV-2 from the kidney of a SARS-CoV-2-positive donor prior to transplantation. The recipient has remained SARS-CoV-2 negative and clinically well, with excellent graft function 120 days post-transplantation.

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Multisite biologic tissue SARS-CoV-2 PCR testing in kidney transplantation from a COVID-positive donor

Abstract

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