Multi-year study of human metapneumovirus infection at a large US Midwestern Medical Referral Center

Gregory C. Gray, Ana W. Capuano, Sharon F. Setterquist, Dean D. Erdman, Newell D. Nobbs, Yacine Abed, Gary V. Doern, Sarah E. Starks, Guy Boivin

Research output: Contribution to journalArticlepeer-review


Background: Because of its recent identification, few multi-year epidemiologic studies of hMPV infection have been reported. Objective: We sought to retrospectively describe hMPV infections among patients evaluated by a large US Midwestern referral laboratory. Study design: Clinical specimens were submitted to a large US Midwest referral hospital from 1 October 2001 to 18 May 2004. RT-PCR was used to retrospectively screen the clinical specimens for human metapneumovirus. Demographic and clinical data were retrieved. Results: 34 (2.6%) of 1294 specimens were hMPV positive. Among these, 21 (62%) were culture positive and available for genetic typing. A previously considered rare genotype of hMPV, B1, was the most common single genotype identified, comprising 9 (43%) of the 21 isolates. Multivariate logistic regression modeling identified patients aged 0.4-9 years (OR = 8.9; 95% CI = 2.0-38.5) and those under intensive care (OR = 3.2; 95% CI = 1.1-8.7) as more likely to have hMPV infection than their peers. Conclusion: In this large referral hospital viral assays more often had evidence of hMPV when they were collected from children receiving intensive care.

Original languageEnglish (US)
Pages (from-to)269-276
Number of pages8
JournalJournal of Clinical Virology
Issue number4
StatePublished - Dec 2006
Externally publishedYes


  • Epidemiology
  • Genotyping
  • Human metapneumovirus
  • Respiratory viruses

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases


Dive into the research topics of 'Multi-year study of human metapneumovirus infection at a large US Midwestern Medical Referral Center'. Together they form a unique fingerprint.

Cite this