MR and TL-201 SPECT imaging with pathologic correlation for the assessment of CNS lymphoma vs. Toxoplasmosis in AIDS patients

L. Ketonen; R. C. De La Pena; J. Villanueva-Meyer

doi:10.1300/J128v02n01_02

MR and TL-201 SPECT imaging with pathologic correlation for the assessment of CNS lymphoma vs. Toxoplasmosis in AIDS patients

L. Ketonen, R. C. De La Pena, J. Villanueva-Meyer

Radiology

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: Analyze the value of Tl-201 (Tl) brain single photon emission computed tomography (SPECT), to differentiate CNS lymphoma from toxoplasmosis in AIDS patients. Material and Methods: Twenty-four AIDS patients with MR enhancing lesion(s), underwent a brain Tl SPECT. Final diagnosis was established by pathology and clinical/MR follow-up. Results: Nine patients had CNS tumor, 9 toxoplasmosis and 6 other non-tumorous lesions. The sensitivity of Tl to diagnose CNS tumor was 77% and the specificity 93%. Two false negative studies corresponded to tumors with significant necrosis. Conclusions: Tl proved useful for differentiating brain neoplasm from toxoplasmosis. Tumors with significant necrosis, did not show the expected increase in Tl uptake. Determination of Tl uptake ratios help detect tumor with faint tracer uptake.

Original language	English (US)
Pages (from-to)	21-42
Number of pages	22
Journal	Journal of Neuro-AIDS
Volume	2
Issue number	1
DOIs	https://doi.org/10.1300/J128v02n01_02
State	Published - 1998

Keywords

AIDS
CNS lymphoma
Magnetic resonance
Thallium-201
Toxoplasmosis

ASJC Scopus subject areas

Clinical Neurology

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10.1300/J128v02n01_02

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title = "MR and TL-201 SPECT imaging with pathologic correlation for the assessment of CNS lymphoma vs. Toxoplasmosis in AIDS patients",

abstract = "Purpose: Analyze the value of Tl-201 (Tl) brain single photon emission computed tomography (SPECT), to differentiate CNS lymphoma from toxoplasmosis in AIDS patients. Material and Methods: Twenty-four AIDS patients with MR enhancing lesion(s), underwent a brain Tl SPECT. Final diagnosis was established by pathology and clinical/MR follow-up. Results: Nine patients had CNS tumor, 9 toxoplasmosis and 6 other non-tumorous lesions. The sensitivity of Tl to diagnose CNS tumor was 77% and the specificity 93%. Two false negative studies corresponded to tumors with significant necrosis. Conclusions: Tl proved useful for differentiating brain neoplasm from toxoplasmosis. Tumors with significant necrosis, did not show the expected increase in Tl uptake. Determination of Tl uptake ratios help detect tumor with faint tracer uptake.",

keywords = "AIDS, CNS lymphoma, Magnetic resonance, Thallium-201, Toxoplasmosis",

author = "L. Ketonen and {De La Pena}, {R. C.} and J. Villanueva-Meyer",

year = "1998",

doi = "10.1300/J128v02n01_02",

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journal = "Journal of Neuro-AIDS",

issn = "1069-7438",

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T1 - MR and TL-201 SPECT imaging with pathologic correlation for the assessment of CNS lymphoma vs. Toxoplasmosis in AIDS patients

AU - Ketonen, L.

AU - De La Pena, R. C.

AU - Villanueva-Meyer, J.

PY - 1998

Y1 - 1998

N2 - Purpose: Analyze the value of Tl-201 (Tl) brain single photon emission computed tomography (SPECT), to differentiate CNS lymphoma from toxoplasmosis in AIDS patients. Material and Methods: Twenty-four AIDS patients with MR enhancing lesion(s), underwent a brain Tl SPECT. Final diagnosis was established by pathology and clinical/MR follow-up. Results: Nine patients had CNS tumor, 9 toxoplasmosis and 6 other non-tumorous lesions. The sensitivity of Tl to diagnose CNS tumor was 77% and the specificity 93%. Two false negative studies corresponded to tumors with significant necrosis. Conclusions: Tl proved useful for differentiating brain neoplasm from toxoplasmosis. Tumors with significant necrosis, did not show the expected increase in Tl uptake. Determination of Tl uptake ratios help detect tumor with faint tracer uptake.

AB - Purpose: Analyze the value of Tl-201 (Tl) brain single photon emission computed tomography (SPECT), to differentiate CNS lymphoma from toxoplasmosis in AIDS patients. Material and Methods: Twenty-four AIDS patients with MR enhancing lesion(s), underwent a brain Tl SPECT. Final diagnosis was established by pathology and clinical/MR follow-up. Results: Nine patients had CNS tumor, 9 toxoplasmosis and 6 other non-tumorous lesions. The sensitivity of Tl to diagnose CNS tumor was 77% and the specificity 93%. Two false negative studies corresponded to tumors with significant necrosis. Conclusions: Tl proved useful for differentiating brain neoplasm from toxoplasmosis. Tumors with significant necrosis, did not show the expected increase in Tl uptake. Determination of Tl uptake ratios help detect tumor with faint tracer uptake.

KW - AIDS

KW - CNS lymphoma

KW - Magnetic resonance

KW - Thallium-201

KW - Toxoplasmosis

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MR and TL-201 SPECT imaging with pathologic correlation for the assessment of CNS lymphoma vs. Toxoplasmosis in AIDS patients

Abstract

Keywords

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