Mouse neuroinvasive phenotype of West Nile virus strains varies depending upon virus genotype

David W.C. Beasley; Li Li; Miguel T. Suderman; Alan D.T. Barrett

doi:10.1006/viro.2002.1372

Mouse neuroinvasive phenotype of West Nile virus strains varies depending upon virus genotype

David W.C. Beasley, Li Li, Miguel T. Suderman, Alan D.T. Barrett

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200 Scopus citations

Abstract

Despite recent advances in the genetics of West Nile (WN) virus, relatively little is known about the molecular basis of virulence of this virus. In particular, although the genotype of the WN virus strain that was recently introduced into North America has been determined, there have been few experimental studies on the virulence phenotype of the virus. We compared genetic and neurovirulence properties of 19 strains of WN virus, including 2 from North America, and observed significant differences in their neuroinvasive phenotype in mice and hamsters that correlated with virus genotype. Virus isolated in North America was found to be highly neuroinvasive with a lack of age-related resistance to infection in mice normally associated with mosquito-borne flaviviruses.

Original language	English (US)
Pages (from-to)	17-23
Number of pages	7
Journal	Virology
Volume	296
Issue number	1
DOIs	https://doi.org/10.1006/viro.2002.1372
State	Published - 2002

ASJC Scopus subject areas

Virology

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title = "Mouse neuroinvasive phenotype of West Nile virus strains varies depending upon virus genotype",

abstract = "Despite recent advances in the genetics of West Nile (WN) virus, relatively little is known about the molecular basis of virulence of this virus. In particular, although the genotype of the WN virus strain that was recently introduced into North America has been determined, there have been few experimental studies on the virulence phenotype of the virus. We compared genetic and neurovirulence properties of 19 strains of WN virus, including 2 from North America, and observed significant differences in their neuroinvasive phenotype in mice and hamsters that correlated with virus genotype. Virus isolated in North America was found to be highly neuroinvasive with a lack of age-related resistance to infection in mice normally associated with mosquito-borne flaviviruses.",

author = "Beasley, {David W.C.} and Li Li and Suderman, {Miguel T.} and Barrett, {Alan D.T.}",

note = "Funding Information: This work was funded in part by NIH Grant AI10984 and a grant from the Clayton Foundation for Research. The authors thank Dr. Robert Tesh and Hilda Guzman for providing virus strains used in this study, and Drs. Mike Holbrook, Jacqui Scherret, and Tom Solomon for critically reading the manuscript.",

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AU - Beasley, David W.C.

AU - Li, Li

AU - Suderman, Miguel T.

AU - Barrett, Alan D.T.

N1 - Funding Information: This work was funded in part by NIH Grant AI10984 and a grant from the Clayton Foundation for Research. The authors thank Dr. Robert Tesh and Hilda Guzman for providing virus strains used in this study, and Drs. Mike Holbrook, Jacqui Scherret, and Tom Solomon for critically reading the manuscript.

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AB - Despite recent advances in the genetics of West Nile (WN) virus, relatively little is known about the molecular basis of virulence of this virus. In particular, although the genotype of the WN virus strain that was recently introduced into North America has been determined, there have been few experimental studies on the virulence phenotype of the virus. We compared genetic and neurovirulence properties of 19 strains of WN virus, including 2 from North America, and observed significant differences in their neuroinvasive phenotype in mice and hamsters that correlated with virus genotype. Virus isolated in North America was found to be highly neuroinvasive with a lack of age-related resistance to infection in mice normally associated with mosquito-borne flaviviruses.

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Mouse neuroinvasive phenotype of West Nile virus strains varies depending upon virus genotype

Abstract

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