Morphological Evaluation of the Heart and Blood Vessels

P. J. Boor

doi:10.1016/B978-0-08-046884-6.00708-9

Morphological Evaluation of the Heart and Blood Vessels

P. J. Boor

Pathology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Methods essential for the morphological evaluation of the heart and blood vessels in toxicological studies are reviewed in this chapter. Focus is on tissue analysis rather than isolated cell studies. The elements of an accurate and thorough morphologic examination are defined. Concepts of gross examination and proper tissue fixation for microscopic and other studies are presented. The general methods of microscopic study including routine histology and special histologic and histochemical preparations are reviewed. Immunohistochemical, electron microscopic, and specialized ultrastructural studies are addressed. Throughout the chapter, basic concepts, the importance of careful sample preparation, and inclusion of proper controls are emphasized.

Original language	English (US)
Title of host publication	Cardiovascular Toxicology
Publisher	Elsevier Inc.
Pages	161-177
Number of pages	17
Volume	6
ISBN (Print)	9780080468686
DOIs	https://doi.org/10.1016/B978-0-08-046884-6.00708-9
State	Published - Aug 12 2010

Keywords

Electron microscopy
Fixation
Gross examination
Histochemistry
Histology
Immunohistochemistry

ASJC Scopus subject areas

General Medicine

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10.1016/B978-0-08-046884-6.00708-9

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AB - Methods essential for the morphological evaluation of the heart and blood vessels in toxicological studies are reviewed in this chapter. Focus is on tissue analysis rather than isolated cell studies. The elements of an accurate and thorough morphologic examination are defined. Concepts of gross examination and proper tissue fixation for microscopic and other studies are presented. The general methods of microscopic study including routine histology and special histologic and histochemical preparations are reviewed. Immunohistochemical, electron microscopic, and specialized ultrastructural studies are addressed. Throughout the chapter, basic concepts, the importance of careful sample preparation, and inclusion of proper controls are emphasized.

KW - Electron microscopy

KW - Fixation

KW - Gross examination

KW - Histochemistry

KW - Histology

KW - Immunohistochemistry

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M3 - Chapter

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BT - Cardiovascular Toxicology

PB - Elsevier Inc.

ER -

Morphological Evaluation of the Heart and Blood Vessels

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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