Morphologic and Genetic Characterization of Ilheus Virus, a Potential Emergent Flavivirus in the Americas

Jessica A. Plante; Kenneth S. Plante; Vsevolod L. Popov; Divya P. Shinde; Steven G. Widen; Michaela Buenemann; Mauricio L. Nogueira; Nikos Vasilakis

doi:10.3390/v15010195

Morphologic and Genetic Characterization of Ilheus Virus, a Potential Emergent Flavivirus in the Americas

Jessica A. Plante, Kenneth S. Plante, Vsevolod L. Popov, Divya P. Shinde, Steven G. Widen, Michaela Buenemann, Mauricio L. Nogueira, Nikos Vasilakis

Research output: Contribution to journal › Article › peer-review

Abstract

Ilheus virus (ILHV) is a mosquito-borne flavivirus circulating throughout Central and South America and the Caribbean. It has been detected in several mosquito genera including Aedes and Culex, and birds are thought to be its primary amplifying and reservoir host. Here, we describe the genomic and morphologic characterization of ten ILHV strains. Our analyses revealed a high conservation of both the 5′- and 3′-untranslated regions but considerable divergence within the open reading frame. We also showed that ILHV displays a typical flavivirus structural and genomic organization. Our work lays the foundation for subsequent ILHV studies to better understand its transmission cycles, pathogenicity, and emergence potential.

Original language	English (US)
Article number	195
Journal	Viruses
Volume	15
Issue number	1
DOIs	https://doi.org/10.3390/v15010195
State	Published - Jan 2023

Keywords

ILHV
Ilheus virus
flavivirus
morphologic and genetic characterization

ASJC Scopus subject areas

Infectious Diseases
Virology

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10.3390/v15010195

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abstract = "Ilheus virus (ILHV) is a mosquito-borne flavivirus circulating throughout Central and South America and the Caribbean. It has been detected in several mosquito genera including Aedes and Culex, and birds are thought to be its primary amplifying and reservoir host. Here, we describe the genomic and morphologic characterization of ten ILHV strains. Our analyses revealed a high conservation of both the 5′- and 3′-untranslated regions but considerable divergence within the open reading frame. We also showed that ILHV displays a typical flavivirus structural and genomic organization. Our work lays the foundation for subsequent ILHV studies to better understand its transmission cycles, pathogenicity, and emergence potential.",

keywords = "ILHV, Ilheus virus, flavivirus, morphologic and genetic characterization",

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T1 - Morphologic and Genetic Characterization of Ilheus Virus, a Potential Emergent Flavivirus in the Americas

AU - Plante, Jessica A.

AU - Plante, Kenneth S.

AU - Popov, Vsevolod L.

AU - Shinde, Divya P.

AU - Widen, Steven G.

AU - Buenemann, Michaela

AU - Nogueira, Mauricio L.

AU - Vasilakis, Nikos

PY - 2023/1

Y1 - 2023/1

N2 - Ilheus virus (ILHV) is a mosquito-borne flavivirus circulating throughout Central and South America and the Caribbean. It has been detected in several mosquito genera including Aedes and Culex, and birds are thought to be its primary amplifying and reservoir host. Here, we describe the genomic and morphologic characterization of ten ILHV strains. Our analyses revealed a high conservation of both the 5′- and 3′-untranslated regions but considerable divergence within the open reading frame. We also showed that ILHV displays a typical flavivirus structural and genomic organization. Our work lays the foundation for subsequent ILHV studies to better understand its transmission cycles, pathogenicity, and emergence potential.

AB - Ilheus virus (ILHV) is a mosquito-borne flavivirus circulating throughout Central and South America and the Caribbean. It has been detected in several mosquito genera including Aedes and Culex, and birds are thought to be its primary amplifying and reservoir host. Here, we describe the genomic and morphologic characterization of ten ILHV strains. Our analyses revealed a high conservation of both the 5′- and 3′-untranslated regions but considerable divergence within the open reading frame. We also showed that ILHV displays a typical flavivirus structural and genomic organization. Our work lays the foundation for subsequent ILHV studies to better understand its transmission cycles, pathogenicity, and emergence potential.

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Morphologic and Genetic Characterization of Ilheus Virus, a Potential Emergent Flavivirus in the Americas

Abstract

Keywords

ASJC Scopus subject areas

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