Morocco underwent a drift of circulating hepatitis C virus subtypes in recent decades

Ikram Brahim; Abdelah Akil; El Mostafa Mtairag; Régis Pouillot; Abdelouhad El Malki; Salwa Nadir; Rhimou Alaoui; Richard Njouom; Pascal Pineau; Sayeh Ezzikouri; Soumaya Benjelloun

doi:10.1007/s00705-011-1193-7

Morocco underwent a drift of circulating hepatitis C virus subtypes in recent decades

Ikram Brahim, Abdelah Akil, El Mostafa Mtairag, Régis Pouillot, Abdelouhad El Malki, Salwa Nadir, Rhimou Alaoui, Richard Njouom, Pascal Pineau, Sayeh Ezzikouri, Soumaya Benjelloun

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Hepatitis C virus (HCV) isolates circulating in Morocco are poorly documented. To determine the subgenotype distribution of HCV in chronically infected patients, serum samples from 185 anti-HCV-positive patients were analyzed. Determination of the HCV genotype and subtype was performed by sequencing the 5′UTR, NS5B and core regions. According to the NS5B phylogeny, the HCV strains primarily belonged to subtypes 1b (75.2%), 2i (19.1%) and 2k (2.8%). Using a Bayesian approach, the mean date of appearance of the most recent common ancestor was estimated to be 1910 for HCV-1b and 1854 for HCV-2i. Although it is currently the most frequent genotype in Morocco and the dominant form in hepatocellular carcinoma, it thus appears that HCV-1b was introduced into the population subsequently to HCV-2i.

Original language	English (US)
Pages (from-to)	515-520
Number of pages	6
Journal	Archives of virology
Volume	157
Issue number	3
DOIs	https://doi.org/10.1007/s00705-011-1193-7
State	Published - Mar 2012
Externally published	Yes

Keywords

Chronic hepatitis C
Genotype
Hepatocellular carcinoma
Morocco
Subtype 1b

ASJC Scopus subject areas

Virology

Access to Document

10.1007/s00705-011-1193-7

Cite this

@article{5946c23f0a4a49159261ec73fd324073,

title = "Morocco underwent a drift of circulating hepatitis C virus subtypes in recent decades",

abstract = "Hepatitis C virus (HCV) isolates circulating in Morocco are poorly documented. To determine the subgenotype distribution of HCV in chronically infected patients, serum samples from 185 anti-HCV-positive patients were analyzed. Determination of the HCV genotype and subtype was performed by sequencing the 5′UTR, NS5B and core regions. According to the NS5B phylogeny, the HCV strains primarily belonged to subtypes 1b (75.2%), 2i (19.1%) and 2k (2.8%). Using a Bayesian approach, the mean date of appearance of the most recent common ancestor was estimated to be 1910 for HCV-1b and 1854 for HCV-2i. Although it is currently the most frequent genotype in Morocco and the dominant form in hepatocellular carcinoma, it thus appears that HCV-1b was introduced into the population subsequently to HCV-2i.",

keywords = "Chronic hepatitis C, Genotype, Hepatocellular carcinoma, Morocco, Subtype 1b",

author = "Ikram Brahim and Abdelah Akil and Mtairag, {El Mostafa} and R{\'e}gis Pouillot and Malki, {Abdelouhad El} and Salwa Nadir and Rhimou Alaoui and Richard Njouom and Pascal Pineau and Sayeh Ezzikouri and Soumaya Benjelloun",

note = "Funding Information: The authors would like to acknowledge all patients for their participation in this study. We thank Dr. Flor H. Pujol for her help. This work was supported by Pasteur Institute of Morocco. ",

year = "2012",

month = mar,

doi = "10.1007/s00705-011-1193-7",

language = "English (US)",

volume = "157",

pages = "515--520",

journal = "Archives of virology",

issn = "0304-8608",

publisher = "Springer",

number = "3",

}

TY - JOUR

T1 - Morocco underwent a drift of circulating hepatitis C virus subtypes in recent decades

AU - Brahim, Ikram

AU - Akil, Abdelah

AU - Mtairag, El Mostafa

AU - Pouillot, Régis

AU - Malki, Abdelouhad El

AU - Nadir, Salwa

AU - Alaoui, Rhimou

AU - Njouom, Richard

AU - Pineau, Pascal

AU - Ezzikouri, Sayeh

AU - Benjelloun, Soumaya

N1 - Funding Information: The authors would like to acknowledge all patients for their participation in this study. We thank Dr. Flor H. Pujol for her help. This work was supported by Pasteur Institute of Morocco.

PY - 2012/3

Y1 - 2012/3

N2 - Hepatitis C virus (HCV) isolates circulating in Morocco are poorly documented. To determine the subgenotype distribution of HCV in chronically infected patients, serum samples from 185 anti-HCV-positive patients were analyzed. Determination of the HCV genotype and subtype was performed by sequencing the 5′UTR, NS5B and core regions. According to the NS5B phylogeny, the HCV strains primarily belonged to subtypes 1b (75.2%), 2i (19.1%) and 2k (2.8%). Using a Bayesian approach, the mean date of appearance of the most recent common ancestor was estimated to be 1910 for HCV-1b and 1854 for HCV-2i. Although it is currently the most frequent genotype in Morocco and the dominant form in hepatocellular carcinoma, it thus appears that HCV-1b was introduced into the population subsequently to HCV-2i.

AB - Hepatitis C virus (HCV) isolates circulating in Morocco are poorly documented. To determine the subgenotype distribution of HCV in chronically infected patients, serum samples from 185 anti-HCV-positive patients were analyzed. Determination of the HCV genotype and subtype was performed by sequencing the 5′UTR, NS5B and core regions. According to the NS5B phylogeny, the HCV strains primarily belonged to subtypes 1b (75.2%), 2i (19.1%) and 2k (2.8%). Using a Bayesian approach, the mean date of appearance of the most recent common ancestor was estimated to be 1910 for HCV-1b and 1854 for HCV-2i. Although it is currently the most frequent genotype in Morocco and the dominant form in hepatocellular carcinoma, it thus appears that HCV-1b was introduced into the population subsequently to HCV-2i.

KW - Chronic hepatitis C

KW - Genotype

KW - Hepatocellular carcinoma

KW - Morocco

KW - Subtype 1b

UR - http://www.scopus.com/inward/record.url?scp=84857799125&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84857799125&partnerID=8YFLogxK

U2 - 10.1007/s00705-011-1193-7

DO - 10.1007/s00705-011-1193-7

M3 - Article

C2 - 22160625

AN - SCOPUS:84857799125

SN - 0304-8608

VL - 157

SP - 515

EP - 520

JO - Archives of virology

JF - Archives of virology

IS - 3

ER -

Morocco underwent a drift of circulating hepatitis C virus subtypes in recent decades

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this