Monitoring refractive index variations in turbid media using phase-sensitive frequency-domain OCT

Kirill V. Larin; Rinat O. Esenaliev; Eunha Kim; Sanghoon Oh; Massoud Motamedi; Thomas E. Milner

doi:10.1117/12.590534

Monitoring refractive index variations in turbid media using phase-sensitive frequency-domain OCT

Kirill V. Larin, Rinat O. Esenaliev, Eunha Kim, Sanghoon Oh, Massoud Motamedi, Thomas E. Milner

Research output: Contribution to journal › Conference article › peer-review

2 Scopus citations

Abstract

Functional imaging of clear and tissue-simulating phantoms using phase-resolved swept-source spectroscopic OCT (PhS-SSOCT) is described. Superior sensitivity of PhS-SSOCT technique to monitor ultra-small changes in sample refractive index is demonstrated using aqueous solutions of glucose and aqueous suspensions of polystyrene microspheres and glucose. Glucose-induced changes in the phase are found to be 0.039 rad/mM and 0.037 rad/mM in the 200 μm-thick cell for clear and turbid media, respectively, that is in good agreement with our previous data obtained using differential-phase time-domain OCT. Obtained results suggest that PhS-SSOCT has a potential for noninvasive, depth-resolved, real-time quantitative monitoring of concentrations of glucose and other analytes with high accuracy.

Original language	English (US)
Article number	70
Pages (from-to)	422-425
Number of pages	4
Journal	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	5690
DOIs	https://doi.org/10.1117/12.590534
State	Published - 2005
Event	Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX - San Jose, CA, United States Duration: Jan 23 2005 → Jan 26 2005

Keywords

OCT
Phase measurements
Swept-source

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics
Radiology Nuclear Medicine and imaging
Biomaterials

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10.1117/12.590534

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title = "Monitoring refractive index variations in turbid media using phase-sensitive frequency-domain OCT",

abstract = "Functional imaging of clear and tissue-simulating phantoms using phase-resolved swept-source spectroscopic OCT (PhS-SSOCT) is described. Superior sensitivity of PhS-SSOCT technique to monitor ultra-small changes in sample refractive index is demonstrated using aqueous solutions of glucose and aqueous suspensions of polystyrene microspheres and glucose. Glucose-induced changes in the phase are found to be 0.039 rad/mM and 0.037 rad/mM in the 200 μm-thick cell for clear and turbid media, respectively, that is in good agreement with our previous data obtained using differential-phase time-domain OCT. Obtained results suggest that PhS-SSOCT has a potential for noninvasive, depth-resolved, real-time quantitative monitoring of concentrations of glucose and other analytes with high accuracy.",

keywords = "OCT, Phase measurements, Swept-source",

author = "Larin, {Kirill V.} and Esenaliev, {Rinat O.} and Eunha Kim and Sanghoon Oh and Massoud Motamedi and Milner, {Thomas E.}",

year = "2005",

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TY - JOUR

T1 - Monitoring refractive index variations in turbid media using phase-sensitive frequency-domain OCT

AU - Larin, Kirill V.

AU - Esenaliev, Rinat O.

AU - Kim, Eunha

AU - Oh, Sanghoon

AU - Motamedi, Massoud

AU - Milner, Thomas E.

PY - 2005

Y1 - 2005

N2 - Functional imaging of clear and tissue-simulating phantoms using phase-resolved swept-source spectroscopic OCT (PhS-SSOCT) is described. Superior sensitivity of PhS-SSOCT technique to monitor ultra-small changes in sample refractive index is demonstrated using aqueous solutions of glucose and aqueous suspensions of polystyrene microspheres and glucose. Glucose-induced changes in the phase are found to be 0.039 rad/mM and 0.037 rad/mM in the 200 μm-thick cell for clear and turbid media, respectively, that is in good agreement with our previous data obtained using differential-phase time-domain OCT. Obtained results suggest that PhS-SSOCT has a potential for noninvasive, depth-resolved, real-time quantitative monitoring of concentrations of glucose and other analytes with high accuracy.

AB - Functional imaging of clear and tissue-simulating phantoms using phase-resolved swept-source spectroscopic OCT (PhS-SSOCT) is described. Superior sensitivity of PhS-SSOCT technique to monitor ultra-small changes in sample refractive index is demonstrated using aqueous solutions of glucose and aqueous suspensions of polystyrene microspheres and glucose. Glucose-induced changes in the phase are found to be 0.039 rad/mM and 0.037 rad/mM in the 200 μm-thick cell for clear and turbid media, respectively, that is in good agreement with our previous data obtained using differential-phase time-domain OCT. Obtained results suggest that PhS-SSOCT has a potential for noninvasive, depth-resolved, real-time quantitative monitoring of concentrations of glucose and other analytes with high accuracy.

KW - OCT

KW - Phase measurements

KW - Swept-source

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JF - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

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Y2 - 23 January 2005 through 26 January 2005

ER -

Monitoring refractive index variations in turbid media using phase-sensitive frequency-domain OCT

Abstract

Keywords

ASJC Scopus subject areas

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