Molecular Mechanisms of Hair Growth and Regeneration: Current Understanding and Novel Paradigms

Khosrow Siamak Houschyar, Mimi R. Borrelli, Christian Tapking, Daniel Popp, Behrus Puladi, Mark Ooms, Malcolm P. Chelliah, Susanne Rein, Dominik Pförringer, Dominik Thor, Georg Reumuth, Christoph Wallner, Ludwik K. Branski, Frank Siemers, Gerrit Grieb, Marcus Lehnhardt, Amir S. Yazdi, Zeshaan N. Maan, Dominik Duscher

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


Hair is a defining feature of mammals and has critical functions, including protection, production of sebum, apocrine sweat and pheromones, social and sexual interactions, thermoregulation, and provision of stem cells for skin homeostasis, regeneration, and repair. The hair follicle (HF) is considered a "mini-organ,"consisting of intricate and well-organized structures which originate from HF stem and progenitor cells. Dermal papilla cells are the main components of the mesenchymal compartments in the hair bulb and are instrumental in generating signals to regulate the behavior of neighboring epithelial cells during the hair cycle. Mesenchymal-epithelial interactions within the dermal papilla niche drive HF embryonic development as well as the postnatal hair growth and regeneration cycle. This review summarizes the current understanding of HF development, repair, and regeneration, with special focus on cell signaling pathways governing these processes. In particular, we discuss emerging paradigms of molecular signaling governing the dermal papilla-epithelial cellular interactions during hair growth and maintenance and the recent progress made towards tissue engineering of human hair follicles.

Original languageEnglish (US)
Pages (from-to)271-280
Number of pages10
Issue number4
StatePublished - Jul 1 2020


  • Follicle
  • Hair growth
  • Hypoxia-inducible factor pathway
  • Regeneration
  • Stem cells
  • Wnt
  • β-Catenin

ASJC Scopus subject areas

  • Dermatology


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