Molecular mechanisms of amyloid oligomers toxicity

Rakez Kayed, Cristian A. Lasagna-Reeves

Research output: Contribution to journalReview articlepeer-review

230 Scopus citations


Amyloid oligomers have emerged as the most toxic species of amyloid-β (Aβ). This hypothesis might explain the lack of correlation between amyloid plaques and memory impairment or cellular dysfunction. However, despite the numerous published research articles supporting the critical role Aβ oligomers in synaptic dysfunction and cell death, the exact definition and mechanism of amyloid oligomers formation and toxicity still elusive. Here we review the evidence supporting the many molecular mechanisms proposed for amyloid oligomers toxicity and suggest that the complexity and dynamic nature of amyloid oligomers may be responsible for the discrepancy among these mechanisms and the proposed cellular targets for amyloid oligomers.

Original languageEnglish (US)
Pages (from-to)S67-S78
JournalJournal of Alzheimer's Disease
Issue numberSUPPL. 1
StatePublished - 2013


  • Alzheimer's disease
  • amyloid
  • amyloid oligomers
  • amyloid toxicity

ASJC Scopus subject areas

  • General Neuroscience
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health


Dive into the research topics of 'Molecular mechanisms of amyloid oligomers toxicity'. Together they form a unique fingerprint.

Cite this