Molecular investigation of a multisource outbreak of Crimean-Congo hemorrhagic fever in the United Arab Emirates

Luis L. Rodriguez; Gary O. Maupin; Thomas G. Ksiazek; Pierre E. Rollin; Ali S. Khan; Tino F. Schwarz; Richard S. Lofts; Jonathan F. Smith; Abdul M. Noor; Clarence J. Peters; Stuart T. Nichol

doi:10.4269/ajtmh.1997.57.512

Molecular investigation of a multisource outbreak of Crimean-Congo hemorrhagic fever in the United Arab Emirates

Luis L. Rodriguez, Gary O. Maupin, Thomas G. Ksiazek, Pierre E. Rollin, Ali S. Khan, Tino F. Schwarz, Richard S. Lofts, Jonathan F. Smith, Abdul M. Noor, Clarence J. Peters, Stuart T. Nichol

Research output: Contribution to journal › Article › peer-review

150 Scopus citations

Abstract

During the investigation of an outbreak of Crimean-Congo hemorrhagic fever (CCHF) in the United Arab Emirates (UAE) between 1994 and 1995, blood samples from suspected CCHF cases and ticks collected from livestock were tested for CCHF virus by antigen-capture ELISA and by a reverse transcription-polymerase chain reaction. Phylogenetic analysis of partial small (S) segment nucleotide sequences from four ticks and five human samples showed that with one exception, all the human and tick viruses clustered along with samples from Pakistan and Madagascar in one distinct lineage. Within this lineage, sequences from the UAE patients were identical or closely related to those from three Hyalomma spp. ticks obtained from livestock recently imported from Somalia. Another sequence from a UAE patient was more closely related to a CCHF virus from Nigeria. These data indicate that the 1994-1995 CCHF epidemic in the UAE was a multisource outbreak possibly associated with importation of CCHF virus-infected livestock and ticks.

Original language	English (US)
Pages (from-to)	512-518
Number of pages	7
Journal	American Journal of Tropical Medicine and Hygiene
Volume	57
Issue number	5
DOIs	https://doi.org/10.4269/ajtmh.1997.57.512
State	Published - 1997
Externally published	Yes

ASJC Scopus subject areas

Parasitology
Virology
Infectious Diseases

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Rodriguez, L. L., Maupin, G. O., Ksiazek, T. G., Rollin, P. E., Khan, A. S., Schwarz, T. F., Lofts, R. S., Smith, J. F., Noor, A. M., Peters, C. J., & Nichol, S. T. (1997). Molecular investigation of a multisource outbreak of Crimean-Congo hemorrhagic fever in the United Arab Emirates. American Journal of Tropical Medicine and Hygiene, 57(5), 512-518. https://doi.org/10.4269/ajtmh.1997.57.512

Rodriguez, LL, Maupin, GO, Ksiazek, TG, Rollin, PE, Khan, AS, Schwarz, TF, Lofts, RS, Smith, JF, Noor, AM, Peters, CJ & Nichol, ST 1997, 'Molecular investigation of a multisource outbreak of Crimean-Congo hemorrhagic fever in the United Arab Emirates', American Journal of Tropical Medicine and Hygiene, vol. 57, no. 5, pp. 512-518. https://doi.org/10.4269/ajtmh.1997.57.512

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abstract = "During the investigation of an outbreak of Crimean-Congo hemorrhagic fever (CCHF) in the United Arab Emirates (UAE) between 1994 and 1995, blood samples from suspected CCHF cases and ticks collected from livestock were tested for CCHF virus by antigen-capture ELISA and by a reverse transcription-polymerase chain reaction. Phylogenetic analysis of partial small (S) segment nucleotide sequences from four ticks and five human samples showed that with one exception, all the human and tick viruses clustered along with samples from Pakistan and Madagascar in one distinct lineage. Within this lineage, sequences from the UAE patients were identical or closely related to those from three Hyalomma spp. ticks obtained from livestock recently imported from Somalia. Another sequence from a UAE patient was more closely related to a CCHF virus from Nigeria. These data indicate that the 1994-1995 CCHF epidemic in the UAE was a multisource outbreak possibly associated with importation of CCHF virus-infected livestock and ticks.",

author = "Rodriguez, {Luis L.} and Maupin, {Gary O.} and Ksiazek, {Thomas G.} and Rollin, {Pierre E.} and Khan, {Ali S.} and Schwarz, {Tino F.} and Lofts, {Richard S.} and Smith, {Jonathan F.} and Noor, {Abdul M.} and Peters, {Clarence J.} and Nichol, {Stuart T.}",

year = "1997",

doi = "10.4269/ajtmh.1997.57.512",

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AU - Schwarz, Tino F.

AU - Lofts, Richard S.

AU - Smith, Jonathan F.

AU - Noor, Abdul M.

AU - Peters, Clarence J.

AU - Nichol, Stuart T.

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Molecular investigation of a multisource outbreak of Crimean-Congo hemorrhagic fever in the United Arab Emirates

Abstract

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