Abstract
In studying bacteriophage T4 - one of the basic models of molecular biology for several decades - there has come a Renaissance, and this virus is now actively used as object of structural biology. The structures of six proteins of the phage particle have recently been determined at atomic resolution by X-ray crystallography. Three-dimensional reconstruction of the infection device - one of the most complex multiprotein components-has been developed on the basis of cryo-electron microscopy images. The further study of bacteriophage T4 structure will allow a better understanding of the regulation of protein folding, assembly of biological structures, and also mechanisms of functioning of the complex biological molecular machines.
Original language | English (US) |
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Pages (from-to) | 1190-1202 |
Number of pages | 13 |
Journal | Biochemistry (Moscow) |
Volume | 69 |
Issue number | 11 |
DOIs | |
State | Published - Nov 2004 |
Externally published | Yes |
Keywords
- 3D reconstruction
- Bacteriophage T4
- Baseplate
- Cryo-electron microscopy
- Infection mechanisms
- Protein structure
- Tail sheath
- Virus structure
- X-ray analysis
ASJC Scopus subject areas
- Biochemistry