Molecular and immunological developments in placentas

Akitoshi Nakashima; Tomoko Shima; Aiko Aoki; Mihoko Kawaguchi; Ippei Yasuda; Sayaka Tsuda; Satoshi Yoneda; Akemi Yamaki-Ushijima; Shi Bin Cheng; Surendra Sharma; Shigeru Saito

doi:10.1016/j.humimm.2021.01.012

Molecular and immunological developments in placentas

Akitoshi Nakashima, Tomoko Shima, Aiko Aoki, Mihoko Kawaguchi, Ippei Yasuda, Sayaka Tsuda, Satoshi Yoneda, Akemi Yamaki-Ushijima, Shi Bin Cheng, Surendra Sharma, Shigeru Saito

Research output: Contribution to journal › Review article › peer-review

Abstract

Cytotrophoblasts differentiate in two directions during early placentation: syncytiotrophoblasts (STBs) and extravillous trophoblasts (EVTs). STBs face maternal immune cells in placentas, and EVTs, which invade the decidua and uterine myometrium, face the cells in the uterus. This situation, in which trophoblasts come into contact with maternal immune cells, is known as the maternal-fetal interface. Despite fetuses and fetus-derived trophoblast cells being of the semi-allogeneic conceptus, fetuses and placentas are not rejected by the maternal immune system because of maternal-fetal tolerance. The acquired tolerance develops during normal placentation, resulting in normal fetal development in humans. In this review, we introduce placental development from the viewpoint of molecular biology. In addition, we discuss how the disruption of placental development could lead to complications in pregnancy, such as hypertensive disorder of pregnancy, fetal growth restriction, or miscarriage.

Original language	English (US)
Pages (from-to)	317-324
Number of pages	8
Journal	Human Immunology
Volume	82
Issue number	5
DOIs	https://doi.org/10.1016/j.humimm.2021.01.012
State	Published - May 2021
Externally published	Yes

Keywords

Autophagy
Placenta
Regulatory T cells
Senescence
Syncytialization

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/j.humimm.2021.01.012

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title = "Molecular and immunological developments in placentas",

abstract = "Cytotrophoblasts differentiate in two directions during early placentation: syncytiotrophoblasts (STBs) and extravillous trophoblasts (EVTs). STBs face maternal immune cells in placentas, and EVTs, which invade the decidua and uterine myometrium, face the cells in the uterus. This situation, in which trophoblasts come into contact with maternal immune cells, is known as the maternal-fetal interface. Despite fetuses and fetus-derived trophoblast cells being of the semi-allogeneic conceptus, fetuses and placentas are not rejected by the maternal immune system because of maternal-fetal tolerance. The acquired tolerance develops during normal placentation, resulting in normal fetal development in humans. In this review, we introduce placental development from the viewpoint of molecular biology. In addition, we discuss how the disruption of placental development could lead to complications in pregnancy, such as hypertensive disorder of pregnancy, fetal growth restriction, or miscarriage.",

keywords = "Autophagy, Placenta, Regulatory T cells, Senescence, Syncytialization",

author = "Akitoshi Nakashima and Tomoko Shima and Aiko Aoki and Mihoko Kawaguchi and Ippei Yasuda and Sayaka Tsuda and Satoshi Yoneda and Akemi Yamaki-Ushijima and Cheng, {Shi Bin} and Surendra Sharma and Shigeru Saito",

note = "Publisher Copyright: {\textcopyright} 2021 American Society for Histocompatibility and Immunogenetics",

year = "2021",

month = may,

doi = "10.1016/j.humimm.2021.01.012",

language = "English (US)",

volume = "82",

pages = "317--324",

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T1 - Molecular and immunological developments in placentas

AU - Nakashima, Akitoshi

AU - Shima, Tomoko

AU - Aoki, Aiko

AU - Kawaguchi, Mihoko

AU - Yasuda, Ippei

AU - Tsuda, Sayaka

AU - Yoneda, Satoshi

AU - Yamaki-Ushijima, Akemi

AU - Cheng, Shi Bin

AU - Sharma, Surendra

AU - Saito, Shigeru

PY - 2021/5

Y1 - 2021/5

N2 - Cytotrophoblasts differentiate in two directions during early placentation: syncytiotrophoblasts (STBs) and extravillous trophoblasts (EVTs). STBs face maternal immune cells in placentas, and EVTs, which invade the decidua and uterine myometrium, face the cells in the uterus. This situation, in which trophoblasts come into contact with maternal immune cells, is known as the maternal-fetal interface. Despite fetuses and fetus-derived trophoblast cells being of the semi-allogeneic conceptus, fetuses and placentas are not rejected by the maternal immune system because of maternal-fetal tolerance. The acquired tolerance develops during normal placentation, resulting in normal fetal development in humans. In this review, we introduce placental development from the viewpoint of molecular biology. In addition, we discuss how the disruption of placental development could lead to complications in pregnancy, such as hypertensive disorder of pregnancy, fetal growth restriction, or miscarriage.

AB - Cytotrophoblasts differentiate in two directions during early placentation: syncytiotrophoblasts (STBs) and extravillous trophoblasts (EVTs). STBs face maternal immune cells in placentas, and EVTs, which invade the decidua and uterine myometrium, face the cells in the uterus. This situation, in which trophoblasts come into contact with maternal immune cells, is known as the maternal-fetal interface. Despite fetuses and fetus-derived trophoblast cells being of the semi-allogeneic conceptus, fetuses and placentas are not rejected by the maternal immune system because of maternal-fetal tolerance. The acquired tolerance develops during normal placentation, resulting in normal fetal development in humans. In this review, we introduce placental development from the viewpoint of molecular biology. In addition, we discuss how the disruption of placental development could lead to complications in pregnancy, such as hypertensive disorder of pregnancy, fetal growth restriction, or miscarriage.

KW - Autophagy

KW - Placenta

KW - Regulatory T cells

KW - Senescence

KW - Syncytialization

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DO - 10.1016/j.humimm.2021.01.012

M3 - Review article

C2 - 33581928

AN - SCOPUS:85100696628

SN - 0198-8859

VL - 82

SP - 317

EP - 324

JO - Human Immunology

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IS - 5

ER -

Molecular and immunological developments in placentas

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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