Modulation of the Hypermetabolic Response after Burn Injury

Ashley Guillory; Craig Porter; Oscar E. Suman; Ramon L. Zapata-Sirvent; Celeste C. Finnerty; David Herndon

doi:10.1016/B978-0-323-47661-4.00029-0

Modulation of the Hypermetabolic Response after Burn Injury

Ashley Guillory, Craig Porter, Oscar E. Suman, Ramon L. Zapata-Sirvent, Celeste C. Finnerty, David Herndon

Surgery

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The hypermetabolic response to severe burn injury can profoundly delay recovery and rehabilitation after the injury. Increased cardiac work, elevated resting energy expenditure, and loss of lean body mass with subsequent decreased muscle strength result from post-burn hypermetabolism. Additionally, elements of the hypermetabolic response remain elevated above normal for up to 3 years. This chapter reviews the metabolic alterations that occur after severe burn injury as well as various pharmacological therapies that are being used and/or investigated for use to attenuate the hypermetabolic response.

Original language	English (US)
Title of host publication	Total Burn Care, Fifth Edition
Publisher	Elsevier
Pages	301-306.e3
ISBN (Electronic)	9780323476614
ISBN (Print)	9780323497428
DOIs	https://doi.org/10.1016/B978-0-323-47661-4.00029-0
State	Published - Jan 1 2017

Keywords

Hypermetabolism
growth hormone
insulin
metformin
oxandrolone
propranolol

ASJC Scopus subject areas

General Medicine

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10.1016/B978-0-323-47661-4.00029-0

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AB - The hypermetabolic response to severe burn injury can profoundly delay recovery and rehabilitation after the injury. Increased cardiac work, elevated resting energy expenditure, and loss of lean body mass with subsequent decreased muscle strength result from post-burn hypermetabolism. Additionally, elements of the hypermetabolic response remain elevated above normal for up to 3 years. This chapter reviews the metabolic alterations that occur after severe burn injury as well as various pharmacological therapies that are being used and/or investigated for use to attenuate the hypermetabolic response.

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ER -

Modulation of the Hypermetabolic Response after Burn Injury

Abstract

Keywords

ASJC Scopus subject areas

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