Modulation of brain NMDA receptors: common mechanism of sigma/PCP receptors and their exogenous and endogenous ligands.

R. Sircar; H. Samaan; R. Nichtenhauser; L. D. Snell; K. M. Johnson; J. Rivier; W. Vale; R. S. Zukin; S. R. Zukin

Modulation of brain NMDA receptors: common mechanism of sigma/PCP receptors and their exogenous and endogenous ligands.

R. Sircar, H. Samaan, R. Nichtenhauser, L. D. Snell, K. M. Johnson, J. Rivier, W. Vale, R. S. Zukin, S. R. Zukin

Research output: Contribution to journal › Article › peer-review

Abstract

Quantitative autoradiographic distribution patterns of sigma/PCP and NMDA receptors show striking similarities but not in all brain areas. We have identified an endogenous ligand of brain PCP receptors which noncompetitively antagonizes NMDA-induced neurotransmitter release from brain slices. These data support the concept that the sigma/PCP receptor ligands may exert their unique behavioral effects by indirect modulation of NMDA-mediated transmission.

Original language	English (US)
Pages (from-to)	157-160
Number of pages	4
Journal	NIDA research monograph
Volume	75
State	Published - 1986
Externally published	Yes

ASJC Scopus subject areas

Medicine (miscellaneous)

Cite this

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title = "Modulation of brain NMDA receptors: common mechanism of sigma/PCP receptors and their exogenous and endogenous ligands.",

abstract = "Quantitative autoradiographic distribution patterns of sigma/PCP and NMDA receptors show striking similarities but not in all brain areas. We have identified an endogenous ligand of brain PCP receptors which noncompetitively antagonizes NMDA-induced neurotransmitter release from brain slices. These data support the concept that the sigma/PCP receptor ligands may exert their unique behavioral effects by indirect modulation of NMDA-mediated transmission.",

author = "R. Sircar and H. Samaan and R. Nichtenhauser and Snell, {L. D.} and Johnson, {K. M.} and J. Rivier and W. Vale and Zukin, {R. S.} and Zukin, {S. R.}",

year = "1986",

language = "English (US)",

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pages = "157--160",

journal = "NIDA research monograph",

issn = "1046-9516",

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T1 - Modulation of brain NMDA receptors

T2 - common mechanism of sigma/PCP receptors and their exogenous and endogenous ligands.

AU - Sircar, R.

AU - Samaan, H.

AU - Nichtenhauser, R.

AU - Snell, L. D.

AU - Johnson, K. M.

AU - Rivier, J.

AU - Vale, W.

AU - Zukin, R. S.

AU - Zukin, S. R.

PY - 1986

Y1 - 1986

N2 - Quantitative autoradiographic distribution patterns of sigma/PCP and NMDA receptors show striking similarities but not in all brain areas. We have identified an endogenous ligand of brain PCP receptors which noncompetitively antagonizes NMDA-induced neurotransmitter release from brain slices. These data support the concept that the sigma/PCP receptor ligands may exert their unique behavioral effects by indirect modulation of NMDA-mediated transmission.

AB - Quantitative autoradiographic distribution patterns of sigma/PCP and NMDA receptors show striking similarities but not in all brain areas. We have identified an endogenous ligand of brain PCP receptors which noncompetitively antagonizes NMDA-induced neurotransmitter release from brain slices. These data support the concept that the sigma/PCP receptor ligands may exert their unique behavioral effects by indirect modulation of NMDA-mediated transmission.

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M3 - Article

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AN - SCOPUS:0022822436

SN - 1046-9516

VL - 75

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JO - NIDA research monograph

JF - NIDA research monograph

ER -

Modulation of brain NMDA receptors: common mechanism of sigma/PCP receptors and their exogenous and endogenous ligands.

Abstract

ASJC Scopus subject areas

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