Modulation of a systemic Semliki Forest virus infection in mice by defective interfering virus

A. D.T. Barrett; N. J. Dimmock

doi:10.1099/0022-1317-65-10-1827

Modulation of a systemic Semliki Forest virus infection in mice by defective interfering virus

A. D.T. Barrett, N. J. Dimmock

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Evidence is presented that defective interfering (DI) Semliki Forest virus (SFV) can modulate the systemic infection in mice initiated by intraperitoneal inoculation of 10 LD₅₀ SFV. Either the mean time of death was delayed or mice failed completely to develop any sign of disease. This prophylactic activity of DI virus was not due to the stimulation of an adaptive immune response since an equivalent amount of non-infectious virus antigen did not change the course of disease.

Original language	English (US)
Pages (from-to)	1827-1831
Number of pages	5
Journal	Journal of General Virology
Volume	65
Issue number	10
DOIs	https://doi.org/10.1099/0022-1317-65-10-1827
State	Published - 1984
Externally published	Yes

ASJC Scopus subject areas

Virology

Access to Document

10.1099/0022-1317-65-10-1827

Cite this

@article{a8030f728e1848189861d1302b0896f5,

title = "Modulation of a systemic Semliki Forest virus infection in mice by defective interfering virus",

abstract = "Evidence is presented that defective interfering (DI) Semliki Forest virus (SFV) can modulate the systemic infection in mice initiated by intraperitoneal inoculation of 10 LD50 SFV. Either the mean time of death was delayed or mice failed completely to develop any sign of disease. This prophylactic activity of DI virus was not due to the stimulation of an adaptive immune response since an equivalent amount of non-infectious virus antigen did not change the course of disease.",

author = "Barrett, {A. D.T.} and Dimmock, {N. J.}",

year = "1984",

doi = "10.1099/0022-1317-65-10-1827",

language = "English (US)",

volume = "65",

pages = "1827--1831",

journal = "Journal of General Virology",

issn = "0022-1317",

publisher = "Society for General Microbiology",

number = "10",

}

TY - JOUR

T1 - Modulation of a systemic Semliki Forest virus infection in mice by defective interfering virus

AU - Barrett, A. D.T.

AU - Dimmock, N. J.

PY - 1984

Y1 - 1984

N2 - Evidence is presented that defective interfering (DI) Semliki Forest virus (SFV) can modulate the systemic infection in mice initiated by intraperitoneal inoculation of 10 LD50 SFV. Either the mean time of death was delayed or mice failed completely to develop any sign of disease. This prophylactic activity of DI virus was not due to the stimulation of an adaptive immune response since an equivalent amount of non-infectious virus antigen did not change the course of disease.

AB - Evidence is presented that defective interfering (DI) Semliki Forest virus (SFV) can modulate the systemic infection in mice initiated by intraperitoneal inoculation of 10 LD50 SFV. Either the mean time of death was delayed or mice failed completely to develop any sign of disease. This prophylactic activity of DI virus was not due to the stimulation of an adaptive immune response since an equivalent amount of non-infectious virus antigen did not change the course of disease.

UR - http://www.scopus.com/inward/record.url?scp=0021203699&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021203699&partnerID=8YFLogxK

U2 - 10.1099/0022-1317-65-10-1827

DO - 10.1099/0022-1317-65-10-1827

M3 - Article

C2 - 6092526

AN - SCOPUS:0021203699

SN - 0022-1317

VL - 65

SP - 1827

EP - 1831

JO - Journal of General Virology

JF - Journal of General Virology

IS - 10

ER -

Modulation of a systemic Semliki Forest virus infection in mice by defective interfering virus

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this