Modification of the radiation response of mouse lung by actinomycin D: Dependence on interval between radiation and drug treatments

Martin Colman; Eileen Zabilansky; J. Leslie Redpath

doi:10.1016/0360-3016(82)90672-1

Modification of the radiation response of mouse lung by actinomycin D: Dependence on interval between radiation and drug treatments

Martin Colman, Eileen Zabilansky, J. Leslie Redpath

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Actinomycin D (0.6 mg/kg, i.p.) enhances the radiation response of mouse lung. The degree of enhancement varies inversely with the interval between radiation and drug treatments. The kinetics of the loss of interaction of the drug with radiation damage is similar to that observed for 'slow repair' of radiation injury to the lung.

Original language	English (US)
Pages (from-to)	511-512
Number of pages	2
Journal	International Journal of Radiation Oncology, Biology, Physics
Volume	8
Issue number	3-4
DOIs	https://doi.org/10.1016/0360-3016(82)90672-1
State	Published - 1982
Externally published	Yes

Keywords

Actinomycin D
Lung
Radiation injury
Type 2 pneumocytes

ASJC Scopus subject areas

Radiation
Oncology
Radiology Nuclear Medicine and imaging
Cancer Research

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10.1016/0360-3016(82)90672-1

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title = "Modification of the radiation response of mouse lung by actinomycin D: Dependence on interval between radiation and drug treatments",

abstract = "Actinomycin D (0.6 mg/kg, i.p.) enhances the radiation response of mouse lung. The degree of enhancement varies inversely with the interval between radiation and drug treatments. The kinetics of the loss of interaction of the drug with radiation damage is similar to that observed for 'slow repair' of radiation injury to the lung.",

keywords = "Actinomycin D, Lung, Radiation injury, Type 2 pneumocytes",

author = "Martin Colman and Eileen Zabilansky and Redpath, {J. Leslie}",

note = "Funding Information: Acknowledgements-This study was supported can Cancer Society Grant No. PDT-l 25.",

year = "1982",

doi = "10.1016/0360-3016(82)90672-1",

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volume = "8",

pages = "511--512",

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T1 - Modification of the radiation response of mouse lung by actinomycin D

T2 - Dependence on interval between radiation and drug treatments

AU - Colman, Martin

AU - Zabilansky, Eileen

AU - Redpath, J. Leslie

N1 - Funding Information: Acknowledgements-This study was supported can Cancer Society Grant No. PDT-l 25.

PY - 1982

Y1 - 1982

N2 - Actinomycin D (0.6 mg/kg, i.p.) enhances the radiation response of mouse lung. The degree of enhancement varies inversely with the interval between radiation and drug treatments. The kinetics of the loss of interaction of the drug with radiation damage is similar to that observed for 'slow repair' of radiation injury to the lung.

AB - Actinomycin D (0.6 mg/kg, i.p.) enhances the radiation response of mouse lung. The degree of enhancement varies inversely with the interval between radiation and drug treatments. The kinetics of the loss of interaction of the drug with radiation damage is similar to that observed for 'slow repair' of radiation injury to the lung.

KW - Actinomycin D

KW - Lung

KW - Radiation injury

KW - Type 2 pneumocytes

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Modification of the radiation response of mouse lung by actinomycin D: Dependence on interval between radiation and drug treatments

Abstract

Keywords

ASJC Scopus subject areas

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