Mild hantaviral disease caused by sin nombre virus in a four–year–old child

Lori R. Armstrong, Ralph T. Bryan, John Sarisky, Ali S. Khan, Thomas Rowe, Thomas Rowe, Paul J. Ettestad, James E. Cheek, C. J. Peters, Pierre Rollin, M. L. Martin, Thomas G. Ksiazek

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Fully intermittent short course chemotherapy regimens have been used successfully in adults but not in children. We report the results on 76 children with tuberculosis, excluding central nervous system tuberculosis and primary pulmonary complex. Isoniazid, rifampin and pyrazinamide were used for treatment. They were randomly allocated to Regimen A (52 doses) and Regimen B (94 doses). Overall efficacy of both schedules was >95% in 27 children with lymphatic, 43 with pulmonary and 6 with disseminated tuberculosis. Compliance in 10 children after 2 to 4 months of therapy was poor because rapid improvement was mistaken by parents for cure. Two children died, probably of underlying lung disease. Follow-up for up to 2 years did not reveal any case of relapse or recurrence of the disease. Therapy for 6 months involving administration of only 52 or 94 doses of drugs was found to be economical, effective and safe for treating children with tuberculosis.

Original languageEnglish (US)
Pages (from-to)1108-1110
Number of pages3
JournalPediatric Infectious Disease Journal
Issue number12
StatePublished - Dec 1995
Externally publishedYes


  • Hantavirus infection
  • Hantavirus pulmonary syndrome
  • Sin nombre virus

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)
  • Infectious Diseases


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