Middle cerebral artery occlusion in rats studied by magnetic resonance imaging

Robert H. Bradley; Thomas A. Ken; Howard M. Eisenberg; Michael J. Quast; Greg A. Ward; Gerald A. Campbell; Gilbert Hillman

doi:10.1161/01.STR.20.8.1032

Middle cerebral artery occlusion in rats studied by magnetic resonance imaging

Robert H. Bradley, Thomas A. Ken, Howard M. Eisenberg, Michael J. Quast, Greg A. Ward, Gerald A. Campbell, Gilbert Hillman

Pathology

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Ischemia due to middle cerebral artery occlusion was studied in 29 rats from 1 to 24 hours after occlusion using magnetic resonance imaging. Images were made before and after the injection of a superparamagnetic iron oxide compound, AMI-25. Subtraction images demonstrated the region of perfusion deficit as early as 1 hour after occlusion, earlier than conventional T₂-weighted images. The area of altered perfusion detected by this technique (subtraction imaging after AMI-25 administration) correlated with that demonstrated by iodoantipyrine autoradiography. Since this magnetic resonance technique can be used to serially estimate the location and size of the ischemic area, the technique can be an important adjunct to metabolic studies of focal ischemia using magnetic resonance spectroscopy. The technique may have clinical applications as well.

Original language	English (US)
Pages (from-to)	1032-1036
Number of pages	5
Journal	Stroke
Volume	20
Issue number	8
DOIs	https://doi.org/10.1161/01.STR.20.8.1032
State	Published - Aug 1989

Keywords

Cerebral ischemia
Magnetic resonance imaging
Rats

ASJC Scopus subject areas

Clinical Neurology
Cardiology and Cardiovascular Medicine
Advanced and Specialized Nursing

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10.1161/01.STR.20.8.1032

Cite this

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AU - Bradley, Robert H.

AU - Ken, Thomas A.

AU - Eisenberg, Howard M.

AU - Quast, Michael J.

AU - Ward, Greg A.

AU - Campbell, Gerald A.

AU - Hillman, Gilbert

PY - 1989/8

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N2 - Ischemia due to middle cerebral artery occlusion was studied in 29 rats from 1 to 24 hours after occlusion using magnetic resonance imaging. Images were made before and after the injection of a superparamagnetic iron oxide compound, AMI-25. Subtraction images demonstrated the region of perfusion deficit as early as 1 hour after occlusion, earlier than conventional T2-weighted images. The area of altered perfusion detected by this technique (subtraction imaging after AMI-25 administration) correlated with that demonstrated by iodoantipyrine autoradiography. Since this magnetic resonance technique can be used to serially estimate the location and size of the ischemic area, the technique can be an important adjunct to metabolic studies of focal ischemia using magnetic resonance spectroscopy. The technique may have clinical applications as well.

AB - Ischemia due to middle cerebral artery occlusion was studied in 29 rats from 1 to 24 hours after occlusion using magnetic resonance imaging. Images were made before and after the injection of a superparamagnetic iron oxide compound, AMI-25. Subtraction images demonstrated the region of perfusion deficit as early as 1 hour after occlusion, earlier than conventional T2-weighted images. The area of altered perfusion detected by this technique (subtraction imaging after AMI-25 administration) correlated with that demonstrated by iodoantipyrine autoradiography. Since this magnetic resonance technique can be used to serially estimate the location and size of the ischemic area, the technique can be an important adjunct to metabolic studies of focal ischemia using magnetic resonance spectroscopy. The technique may have clinical applications as well.

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Middle cerebral artery occlusion in rats studied by magnetic resonance imaging

Abstract

Keywords

ASJC Scopus subject areas

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