Microscopic observation drug susceptibility assay for rapid diagnosis of lymph node tuberculosis and detection of drug resistance

Lymph Node TB Working Group, Peru

doi:10.1128/JCM.02227-15

Microscopic observation drug susceptibility assay for rapid diagnosis of lymph node tuberculosis and detection of drug resistance

Lymph Node TB Working Group, Peru

Research output: Contribution to journal › Article › peer-review

Abstract

In this study, 132 patients with lymphadenopathy were investigated. Fifty-two (39.4%) were diagnosed with tuberculosis (TB). The microscopic observation drug susceptibility (MODS) assay provided rapid (13 days), accurate diagnosis (sensitivity, 65.4%) and reliable drug susceptibility testing (DST). Despite its lower sensitivity than that of other methods, its faster results and simultaneous DST are advantageous in resource-poor settings, supporting the incorporation of MODS into diagnostic algorithms for extrapulmonary TB.

Original language	English (US)
Pages (from-to)	185-189
Number of pages	5
Journal	Journal of Clinical Microbiology
Volume	54
Issue number	1
DOIs	https://doi.org/10.1128/JCM.02227-15
State	Published - Jan 2016
Externally published	Yes

ASJC Scopus subject areas

Microbiology (medical)

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title = "Microscopic observation drug susceptibility assay for rapid diagnosis of lymph node tuberculosis and detection of drug resistance",

abstract = "In this study, 132 patients with lymphadenopathy were investigated. Fifty-two (39.4%) were diagnosed with tuberculosis (TB). The microscopic observation drug susceptibility (MODS) assay provided rapid (13 days), accurate diagnosis (sensitivity, 65.4%) and reliable drug susceptibility testing (DST). Despite its lower sensitivity than that of other methods, its faster results and simultaneous DST are advantageous in resource-poor settings, supporting the incorporation of MODS into diagnostic algorithms for extrapulmonary TB.",

author = "{Lymph Node TB Working Group, Peru} and Kirwan, {Daniela E.} and Cesar Ugarte-Gil and Gilman, {Robert H.} and Hasan Rizvi and Eduardo Ticona and Gonzalo Chavez and Cabrera, {Jos{\'e} Luis} and Matos, {Eduardo D.} and Evans, {Carlton A.} and Moore, {David A.J.} and Friedland, {Jon S.}",

year = "2016",

month = jan,

doi = "10.1128/JCM.02227-15",

language = "English (US)",

volume = "54",

pages = "185--189",

journal = "Journal of Clinical Microbiology",

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publisher = "American Society for Microbiology",

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TY - JOUR

T1 - Microscopic observation drug susceptibility assay for rapid diagnosis of lymph node tuberculosis and detection of drug resistance

AU - Lymph Node TB Working Group, Peru

AU - Kirwan, Daniela E.

AU - Ugarte-Gil, Cesar

AU - Gilman, Robert H.

AU - Rizvi, Hasan

AU - Ticona, Eduardo

AU - Chavez, Gonzalo

AU - Cabrera, José Luis

AU - Matos, Eduardo D.

AU - Evans, Carlton A.

AU - Moore, David A.J.

AU - Friedland, Jon S.

PY - 2016/1

Y1 - 2016/1

N2 - In this study, 132 patients with lymphadenopathy were investigated. Fifty-two (39.4%) were diagnosed with tuberculosis (TB). The microscopic observation drug susceptibility (MODS) assay provided rapid (13 days), accurate diagnosis (sensitivity, 65.4%) and reliable drug susceptibility testing (DST). Despite its lower sensitivity than that of other methods, its faster results and simultaneous DST are advantageous in resource-poor settings, supporting the incorporation of MODS into diagnostic algorithms for extrapulmonary TB.

AB - In this study, 132 patients with lymphadenopathy were investigated. Fifty-two (39.4%) were diagnosed with tuberculosis (TB). The microscopic observation drug susceptibility (MODS) assay provided rapid (13 days), accurate diagnosis (sensitivity, 65.4%) and reliable drug susceptibility testing (DST). Despite its lower sensitivity than that of other methods, its faster results and simultaneous DST are advantageous in resource-poor settings, supporting the incorporation of MODS into diagnostic algorithms for extrapulmonary TB.

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JO - Journal of Clinical Microbiology

JF - Journal of Clinical Microbiology

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Microscopic observation drug susceptibility assay for rapid diagnosis of lymph node tuberculosis and detection of drug resistance

Abstract

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