TY - JOUR
T1 - Metapneumovirus and acute wheezing in children
AU - Jartti, Tuomas
AU - Van Den Hoogen, Bernadette
AU - Garofalo, Roberto P.
AU - Osterhaus, Albert D.M.E.
AU - Ruuskanen, Olli
N1 - Funding Information:
The study was supported by the Academy of Finland, in part by the US National Institutes of Health/National Institute of Allergy and Infectious Diseases grants AI 15939 and P01AI 46004, and by the Dutch Sophia Foundation for Medical Research grant SSWO378. Leiras Pharmaceuticals, Finland, provided prednisolone and placebo preparations. The study sponsors had no role in study design, data collection, data analysis, data interpretation, or in the writing of the report.
PY - 2002/11/2
Y1 - 2002/11/2
N2 - A new respiratory virus, human metapneumovirus, was recently identified. We detected this virus by PCR in ten (8%) of 132 consecutive children admitted to Turku Hospital, Finland, for acute expiratory wheezing (median age 7 months, range 4-25). The mean duration of hospital stay was 2.5 days (SD 1.6) and mean duration of respiratory symptoms was 19 days (8). The white blood cell count, C-reactive protein, and regulated upon activation, normal T-cell-expressed and T-cell-secreted (RANTES) concentrations in nasal secretion remained low, whereas interleukin 8 concentrations in nasal secretion were high. Human metapneumovirus is a clinically important causative agent of acute wheezing in young children.
AB - A new respiratory virus, human metapneumovirus, was recently identified. We detected this virus by PCR in ten (8%) of 132 consecutive children admitted to Turku Hospital, Finland, for acute expiratory wheezing (median age 7 months, range 4-25). The mean duration of hospital stay was 2.5 days (SD 1.6) and mean duration of respiratory symptoms was 19 days (8). The white blood cell count, C-reactive protein, and regulated upon activation, normal T-cell-expressed and T-cell-secreted (RANTES) concentrations in nasal secretion remained low, whereas interleukin 8 concentrations in nasal secretion were high. Human metapneumovirus is a clinically important causative agent of acute wheezing in young children.
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U2 - 10.1016/S0140-6736(02)11391-2
DO - 10.1016/S0140-6736(02)11391-2
M3 - Article
C2 - 12423987
AN - SCOPUS:0037010447
SN - 0140-6736
VL - 360
SP - 1393
EP - 1394
JO - Lancet
JF - Lancet
IS - 9343
ER -