Metabolic activation and biological effects of nitrosamines in the mammalian lung

Hildegrand M. Schulle, Miriam Falzon, James B. McMahon

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


Nitrosamines and their precursors are among the most common contaminants of our environment, and may of therm are highly carcinogenic. Nitrosamines are believed to require metabolic activation in the host organism, and many of them demonstrate a pronounced organ and cell type specificity. This review summarizes recent in vivo and in vitro experiments which focus on the mechanisms of nitrosamine-induced lung carcinogenesis. Currently available in vivo and in vitro data suggest that nitrosamines may be metabolized by cytochrome P-450, prostaglandin endoperoxide synthetase, or monoamine oxidases. The presence of one or the other of these enzyme systems may be partially responsible for the cell type-specific effects of this class of chemicals. Moreover, evidence in vitro suggests selective uptake of nitrosamines by cell type-specific receptors, a phenomenon which offers a more logical explanation than previously published theories for the selectively of biological effects exerted by nitrosamines.

Original languageEnglish (US)
Pages (from-to)95-103
Number of pages9
JournalPharmacology and Therapeutics
Issue number1
StatePublished - 1990
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)


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