TY - JOUR
T1 - Messenger RNA reprogramming by spliceosome-mediated RNA trans-splicing
AU - Garcia-Blanco, Mariano A.
PY - 2003/8
Y1 - 2003/8
N2 - In the human genome, the majority of protein-encoding genes are interrupted by introns, which are removed from primary transcripts by a macromolecular enzyme known as the spliceosome. Spliceosomes can constitutively remove all the introns in a primary transcript to yield a fully spliced mRNA or alternatively splice primary transcripts leading to the production of many different mRNAs from one gene. This review examines how spliceosomes can recombine two primary transcripts in trans to reprogram messenger RNAs.
AB - In the human genome, the majority of protein-encoding genes are interrupted by introns, which are removed from primary transcripts by a macromolecular enzyme known as the spliceosome. Spliceosomes can constitutively remove all the introns in a primary transcript to yield a fully spliced mRNA or alternatively splice primary transcripts leading to the production of many different mRNAs from one gene. This review examines how spliceosomes can recombine two primary transcripts in trans to reprogram messenger RNAs.
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U2 - 10.1172/JCI200319462
DO - 10.1172/JCI200319462
M3 - Review article
C2 - 12925685
AN - SCOPUS:0141608626
SN - 0021-9738
VL - 112
SP - 474
EP - 480
JO - Journal of Clinical Investigation
JF - Journal of Clinical Investigation
IS - 4
ER -