TY - JOUR
T1 - Mercapturic acid pathway enzymes in bovine ocular lens, cornea, retina and retinal pigmented epithelium
AU - Saneto, Russell P.
AU - Awasthi, Yogesh C.
AU - Srivastava, Satish K.
N1 - Funding Information:
This investigation was supported by PHS grant numbers EY 01677, CA 27967 and 1 T32 GM 07204, awarded by the National Eye Institute, National Cancer Institute and Institute of General Medical Sciences.
PY - 1982/8
Y1 - 1982/8
N2 - Analogous to the liver, ocular tissues contain large concentrations of glutathione and are exposed to potentially damaging chemical compounds. Since glutathione has been shown to have a detoxification function, via mercapturic acid production in the liver, we investigated whether glutathione has a similar function in ocular tissues. We have demonstrated the presence of all of the enzymes involved in the mercapturic acid pathway i.e. glutathione S-transferase, gamma-glutamyl transpeptidase, cysteinylglycinase, and N-acetyl transferase, in the ocular tissues of bovine lens, cornea, retina, and retinal pigmented epithelium. Therefore glutathione may have another function in ocular tissues, that of the detoxification of xenobiotics.
AB - Analogous to the liver, ocular tissues contain large concentrations of glutathione and are exposed to potentially damaging chemical compounds. Since glutathione has been shown to have a detoxification function, via mercapturic acid production in the liver, we investigated whether glutathione has a similar function in ocular tissues. We have demonstrated the presence of all of the enzymes involved in the mercapturic acid pathway i.e. glutathione S-transferase, gamma-glutamyl transpeptidase, cysteinylglycinase, and N-acetyl transferase, in the ocular tissues of bovine lens, cornea, retina, and retinal pigmented epithelium. Therefore glutathione may have another function in ocular tissues, that of the detoxification of xenobiotics.
KW - cornea
KW - detoxification
KW - glutathione
KW - lens
KW - mercapturic acid pathway
KW - retina
KW - retinal pigmented epithelium
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U2 - 10.1016/S0014-4835(82)80059-6
DO - 10.1016/S0014-4835(82)80059-6
M3 - Article
C2 - 6129991
AN - SCOPUS:0019989559
SN - 0014-4835
VL - 35
SP - 107
EP - 111
JO - Experimental Eye Research
JF - Experimental Eye Research
IS - 2
ER -