Mechanism of lithium-induced augmentation of T-cell proliferation

Eugene J. Kucharz; Stanislaw Sierakowski; Nigel D. Staite; James S. Goodwin

doi:10.1016/0192-0561(88)90056-2

Mechanism of lithium-induced augmentation of T-cell proliferation

Eugene J. Kucharz, Stanislaw Sierakowski, Nigel D. Staite, James S. Goodwin

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

The mechanism whereby lithium augments mitogen-stimulated T-cell proliferation was investigated. Lithium in a concentration of 5mM caused a significant increase in interleukin 2 (IL-2) production after phytohemagglutinin (PHA) stimulation. Lithium also caused an increase in interleukin 1 production from peripheral blood monocytes. Lithium did not influence the expression of IL-2 receptors on T-cells. However, lithium did result in increased proliferative response to IL-2 in an IL-2 responsive cell line. Thus, lithium influences the T-cell proliferation response to mitogens in several ways, by stimulation of lymphokine and monokine production as well as by augmenting the response of IL-2 responsive cells to IL-2.

Original language	English (US)
Pages (from-to)	253-259
Number of pages	7
Journal	International Journal of Immunopharmacology
Volume	10
Issue number	3
DOIs	https://doi.org/10.1016/0192-0561(88)90056-2
State	Published - 1988
Externally published	Yes

ASJC Scopus subject areas

Immunology
Pharmacology

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title = "Mechanism of lithium-induced augmentation of T-cell proliferation",

abstract = "The mechanism whereby lithium augments mitogen-stimulated T-cell proliferation was investigated. Lithium in a concentration of 5mM caused a significant increase in interleukin 2 (IL-2) production after phytohemagglutinin (PHA) stimulation. Lithium also caused an increase in interleukin 1 production from peripheral blood monocytes. Lithium did not influence the expression of IL-2 receptors on T-cells. However, lithium did result in increased proliferative response to IL-2 in an IL-2 responsive cell line. Thus, lithium influences the T-cell proliferation response to mitogens in several ways, by stimulation of lymphokine and monokine production as well as by augmenting the response of IL-2 responsive cells to IL-2.",

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AU - Kucharz, Eugene J.

AU - Sierakowski, Stanislaw

AU - Staite, Nigel D.

AU - Goodwin, James S.

PY - 1988

Y1 - 1988

N2 - The mechanism whereby lithium augments mitogen-stimulated T-cell proliferation was investigated. Lithium in a concentration of 5mM caused a significant increase in interleukin 2 (IL-2) production after phytohemagglutinin (PHA) stimulation. Lithium also caused an increase in interleukin 1 production from peripheral blood monocytes. Lithium did not influence the expression of IL-2 receptors on T-cells. However, lithium did result in increased proliferative response to IL-2 in an IL-2 responsive cell line. Thus, lithium influences the T-cell proliferation response to mitogens in several ways, by stimulation of lymphokine and monokine production as well as by augmenting the response of IL-2 responsive cells to IL-2.

AB - The mechanism whereby lithium augments mitogen-stimulated T-cell proliferation was investigated. Lithium in a concentration of 5mM caused a significant increase in interleukin 2 (IL-2) production after phytohemagglutinin (PHA) stimulation. Lithium also caused an increase in interleukin 1 production from peripheral blood monocytes. Lithium did not influence the expression of IL-2 receptors on T-cells. However, lithium did result in increased proliferative response to IL-2 in an IL-2 responsive cell line. Thus, lithium influences the T-cell proliferation response to mitogens in several ways, by stimulation of lymphokine and monokine production as well as by augmenting the response of IL-2 responsive cells to IL-2.

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Mechanism of lithium-induced augmentation of T-cell proliferation

Abstract

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