Mechanism for the suppression of γ-interferon responsiveness in mice after thermal injury

F. Suzuki, R. B. Pollard

Research output: Contribution to journalArticlepeer-review

54 Scopus citations


As reported previously, γ-interferon production was decreased after the administration of inducers to thermally injured mice as compared with noninjured controls. Similarly, spleen cells from injured mice had decreased ability to produce interferon in vitro after stimulation with inducers. The present study demonstrated that the decrease in interferon production was associated with the presence of suppressor cells in the spleens of burned mice that were capable of inhibiting interferon production by normal splenic lymphocytes in vitro. Passive transfer of spleen cells containing suppressor cell activity derived from injured mice induced suppression in normal mice, and the time of the appearance of suppressor cell activity in injured mouse spleens closely approximated the time of the appearance of the suppression of interferon production observed in mice after thermal injury. The suppressor cells were characterized as a population of macrophages by the following: they adhered to plastic surface and could be removed from spleen cells by carbonyl-iron treatment; treatment of plastic-adherent cells with anti-Thy-1.2 and anti-mouse immunoglobulin antisera followed by complement failed to abrogate the suppression produced by these cells.

Original languageEnglish (US)
Pages (from-to)1811-1815
Number of pages5
JournalJournal of Immunology
Issue number5
StatePublished - 1982
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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