Maternal obesity exacerbates insulitis and type 1 diabetes in non-obese diabetic mice

Hui Wang, Yansong Xue, Baolin Wang, Junxing Zhao, Xu Yan, Yan Huang, Min Du, Mei Jun Zhu

Research output: Contribution to journalArticlepeer-review


Accompanying the dramatic increase in maternal obesity, the incidence of type 1 diabetes (T1D) in children is also rapidly increasing. The objective of this study was to explore the effects of maternal obesity on the incidence of T1D in offspring using non-obese diabetic (NOD) mice, a common model for TID. Four-week-old female NOD mice were fed either a control diet (10% energy from fat, CON) or a high-fat diet (60% energy from fat) for 8 weeks before mating. Mice were maintained in their respective diets during pregnancy and lactation. All offspring mice were fed the CON to 16 weeks. Female offspring (16-week-old) born to obese dams showed more severe islet lymphocyte infiltration (major manifestation of insulitis) (P<0.01), concomitant with elevated nuclear factor kappa-light-chain-enhancer of activated B cells p65 signaling (P!0.01) and tumor necrosis factor alpha protein level (P<0.05) in the pancreas. In addition, maternal obesity resulted in impaired (P<0.05) glucose tolerance and lower (P<0.05) serum insulin levels in offspring. In conclusion, maternal obesity resulted in exacerbated insulitis and inflammation in the pancreas of NOD offspring mice, providing a possible explanation for the increased incidence of T1D in children.

Original languageEnglish (US)
Pages (from-to)73-79
Number of pages7
Issue number1
StatePublished - Jul 1 2014
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology
  • Obstetrics and Gynecology
  • Cell Biology
  • Reproductive Medicine
  • Embryology


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