Maternal immune response to HIV-1 and perinatal trasmission

A. L. Landay; J. N. Siegel; K. Rich

doi:10.1016/S0889-8561(05)70009-6

Maternal immune response to HIV-1 and perinatal trasmission

A. L. Landay, J. N. Siegel, K. Rich

Research output: Contribution to journal › Article › peer-review

Abstract

Pregnancy represents a time of dynamic physiologic changes in immunoregulation with a predominant Type 2 immune response. HIV infection during pregnancy impacts the immune system, especially CD4 depletion and cellular activation. How these immune factors ultimately determine maternal-fetal HIV transmission is extremely complex. We are now beginning to understand the immune factors that influence HIV transmission, both systemically and at the placental interface. A better understanding of these factors will potentially lead to development of new therapeutic intervention for reducing maternal-fetal HIV transmission.

Original language	English (US)
Pages (from-to)	355-369
Number of pages	15
Journal	Immunology and Allergy Clinics of North America
Volume	18
Issue number	2
DOIs	https://doi.org/10.1016/S0889-8561(05)70009-6
State	Published - 1998
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/S0889-8561(05)70009-6

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abstract = "Pregnancy represents a time of dynamic physiologic changes in immunoregulation with a predominant Type 2 immune response. HIV infection during pregnancy impacts the immune system, especially CD4 depletion and cellular activation. How these immune factors ultimately determine maternal-fetal HIV transmission is extremely complex. We are now beginning to understand the immune factors that influence HIV transmission, both systemically and at the placental interface. A better understanding of these factors will potentially lead to development of new therapeutic intervention for reducing maternal-fetal HIV transmission.",

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AU - Rich, K.

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Maternal immune response to HIV-1 and perinatal trasmission

Abstract

ASJC Scopus subject areas

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