Maternal immune response to HIV-1 and perinatal trasmission

A. L. Landay, J. N. Siegel, K. Rich

Research output: Contribution to journalArticlepeer-review


Pregnancy represents a time of dynamic physiologic changes in immunoregulation with a predominant Type 2 immune response. HIV infection during pregnancy impacts the immune system, especially CD4 depletion and cellular activation. How these immune factors ultimately determine maternal-fetal HIV transmission is extremely complex. We are now beginning to understand the immune factors that influence HIV transmission, both systemically and at the placental interface. A better understanding of these factors will potentially lead to development of new therapeutic intervention for reducing maternal-fetal HIV transmission.

Original languageEnglish (US)
Pages (from-to)355-369
Number of pages15
JournalImmunology and Allergy Clinics of North America
Issue number2
StatePublished - 1998
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


Dive into the research topics of 'Maternal immune response to HIV-1 and perinatal trasmission'. Together they form a unique fingerprint.

Cite this