Mass spectrometry of peptides in neuroscience

Carol L. Nilsson, Gösta Karlsson, Jonas Bergquist, Ann Westman, Rolf Ekman

Research output: Contribution to journalReview articlepeer-review

49 Scopus citations


This review focuses on the contributions of modern mass spectrometry to neuropeptide research. An introduction to newer mass spectrometric techniques is provided. Also, the use of mass spectrometry in combination with high- resolution separation techniques for neuropeptide identification in biological samples is illustrated. The amino acid sequence information that is important for the identification and analysis of known, novel, or chemically modified neuropeptides may be obtained using mass spectrometric techniques. Because mass spectrometry techniques can be used to reflect the dynamic properties associated with neuropeptide processing in biological systems, they may be used in the future to monitor peptide profiles within organisms in response to environmental challenges such as disease and stress.

Original languageEnglish (US)
Pages (from-to)781-789
Number of pages9
Issue number4
StatePublished - Apr 1998
Externally publishedYes


  • Electrospray ionization mass spectrometry
  • Matrix-assisted laser desorption/ionization mass spectrometry
  • Neuropeptides

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience


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