Marburg and Ravn Virus Infections Do Not Cause Observable Disease in Ferrets

Gary Wong, Zirui Zhang, Shihua He, Marc Antoine De La Vega, Kevin Tierney, Geoff Soule, Kaylie Tran, Lisa Fernando, Xiangguo Qiu

Research output: Contribution to journalArticlepeer-review


Ferrets are used for studying infections with wild-type Ebola virus isolates. Here, we investigated whether these animals are also susceptible to wild-type isolates of Marburg virus (MARV). Ferrets were challenged intramuscularly or intranasally with MARV strain Angola and monitored for 3 weeks. Unexpectedly, the animals neither showed observable signs of disease nor died of infection, and viremia was not detected after challenge. All animals were seropositive for MARV-specific immunoglobulin antibodies. Confirmatory studies with MARV strain Musoke and Ravn virus yielded the same outcomes. Therefore, ferrets may be of limited usefulness for studying the pathogenesis of MARV and Ravn virus infections.

Original languageEnglish (US)
Pages (from-to)S471-S474
JournalJournal of Infectious Diseases
StatePublished - Nov 22 2018
Externally publishedYes


  • Marburg virus
  • Ravn virus
  • animal models
  • experimental infection.
  • ferrets
  • pathogenesis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases


Dive into the research topics of 'Marburg and Ravn Virus Infections Do Not Cause Observable Disease in Ferrets'. Together they form a unique fingerprint.

Cite this