Marburg and Ravn Virus Infections Do Not Cause Observable Disease in Ferrets

Gary Wong; Zirui Zhang; Shihua He; Marc Antoine De La Vega; Kevin Tierney; Geoff Soule; Kaylie Tran; Lisa Fernando; Xiangguo Qiu

doi:10.1093/infdis/jiy245

Marburg and Ravn Virus Infections Do Not Cause Observable Disease in Ferrets

Gary Wong, Zirui Zhang, Shihua He, Marc Antoine De La Vega, Kevin Tierney, Geoff Soule, Kaylie Tran, Lisa Fernando, Xiangguo Qiu

Research output: Contribution to journal › Article › peer-review

Abstract

Ferrets are used for studying infections with wild-type Ebola virus isolates. Here, we investigated whether these animals are also susceptible to wild-type isolates of Marburg virus (MARV). Ferrets were challenged intramuscularly or intranasally with MARV strain Angola and monitored for 3 weeks. Unexpectedly, the animals neither showed observable signs of disease nor died of infection, and viremia was not detected after challenge. All animals were seropositive for MARV-specific immunoglobulin antibodies. Confirmatory studies with MARV strain Musoke and Ravn virus yielded the same outcomes. Therefore, ferrets may be of limited usefulness for studying the pathogenesis of MARV and Ravn virus infections.

Original language	English (US)
Pages (from-to)	S471-S474
Journal	Journal of Infectious Diseases
Volume	218
DOIs	https://doi.org/10.1093/infdis/jiy245
State	Published - Nov 22 2018
Externally published	Yes

Keywords

Marburg virus
Ravn virus
animal models
experimental infection.
ferrets
pathogenesis

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

Access to Document

10.1093/infdis/jiy245

Cite this

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title = "Marburg and Ravn Virus Infections Do Not Cause Observable Disease in Ferrets",

abstract = "Ferrets are used for studying infections with wild-type Ebola virus isolates. Here, we investigated whether these animals are also susceptible to wild-type isolates of Marburg virus (MARV). Ferrets were challenged intramuscularly or intranasally with MARV strain Angola and monitored for 3 weeks. Unexpectedly, the animals neither showed observable signs of disease nor died of infection, and viremia was not detected after challenge. All animals were seropositive for MARV-specific immunoglobulin antibodies. Confirmatory studies with MARV strain Musoke and Ravn virus yielded the same outcomes. Therefore, ferrets may be of limited usefulness for studying the pathogenesis of MARV and Ravn virus infections.",

keywords = "Marburg virus, Ravn virus, animal models, experimental infection., ferrets, pathogenesis",

author = "Gary Wong and Zirui Zhang and Shihua He and {De La Vega}, {Marc Antoine} and Kevin Tierney and Geoff Soule and Kaylie Tran and Lisa Fernando and Xiangguo Qiu",

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T1 - Marburg and Ravn Virus Infections Do Not Cause Observable Disease in Ferrets

AU - Wong, Gary

AU - Zhang, Zirui

AU - He, Shihua

AU - De La Vega, Marc Antoine

AU - Tierney, Kevin

AU - Soule, Geoff

AU - Tran, Kaylie

AU - Fernando, Lisa

AU - Qiu, Xiangguo

PY - 2018/11/22

Y1 - 2018/11/22

N2 - Ferrets are used for studying infections with wild-type Ebola virus isolates. Here, we investigated whether these animals are also susceptible to wild-type isolates of Marburg virus (MARV). Ferrets were challenged intramuscularly or intranasally with MARV strain Angola and monitored for 3 weeks. Unexpectedly, the animals neither showed observable signs of disease nor died of infection, and viremia was not detected after challenge. All animals were seropositive for MARV-specific immunoglobulin antibodies. Confirmatory studies with MARV strain Musoke and Ravn virus yielded the same outcomes. Therefore, ferrets may be of limited usefulness for studying the pathogenesis of MARV and Ravn virus infections.

AB - Ferrets are used for studying infections with wild-type Ebola virus isolates. Here, we investigated whether these animals are also susceptible to wild-type isolates of Marburg virus (MARV). Ferrets were challenged intramuscularly or intranasally with MARV strain Angola and monitored for 3 weeks. Unexpectedly, the animals neither showed observable signs of disease nor died of infection, and viremia was not detected after challenge. All animals were seropositive for MARV-specific immunoglobulin antibodies. Confirmatory studies with MARV strain Musoke and Ravn virus yielded the same outcomes. Therefore, ferrets may be of limited usefulness for studying the pathogenesis of MARV and Ravn virus infections.

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KW - animal models

KW - experimental infection.

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KW - pathogenesis

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Marburg and Ravn Virus Infections Do Not Cause Observable Disease in Ferrets

Abstract

Keywords

ASJC Scopus subject areas

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