Maintenance of Viral Suppression in Human Immunodeficiency Virus Controllers despite Waning T-Cell Responses during Antiretroviral Therapy

Nikolaus Jilg; Pilar Garcia-Broncano; Michael Peluso; Florencia P. Segal; Ronald J. Bosch; Carla Roberts-Toler; Samantha M.Y. Chen; Cornelius N. Van Dam; Michael C. Keefer; Daniel R. Kuritzkes; Alan L. Landay; Steven Deeks; Xu G. Yu; Paul E. Sax; Jonathan Z. Li

doi:10.1093/infdis/jiaa294

Maintenance of Viral Suppression in Human Immunodeficiency Virus Controllers despite Waning T-Cell Responses during Antiretroviral Therapy

Nikolaus Jilg, Pilar Garcia-Broncano, Michael Peluso, Florencia P. Segal, Ronald J. Bosch, Carla Roberts-Toler, Samantha M.Y. Chen, Cornelius N. Van Dam, Michael C. Keefer, Daniel R. Kuritzkes, Alan L. Landay, Steven Deeks, Xu G. Yu, Paul E. Sax, Jonathan Z. Li

Research output: Contribution to journal › Article › peer-review

Abstract

AIDS Clinical Trials Group study A5308 found reduced T-cell activation and exhaustion in human immunodeficiency virus (HIV) controllers start antiretroviral therapy (ART). We further assessed HIV-specific T-cell responses and post-ART viral loads. Before ART, the 31% of participants with persistently undetectable viremia had more robust HIV-specific T-cell responses. During ART, significant decreases were observed in a broad range of T-cell responses. Eight controllers in A5308 and the Study of the Consequences of the Protease Inhibitor Era (SCOPE) cohort showed no viremia above the level of quantification in the first 12 weeks after ART discontinuation. ART significantly reduced HIV-specific T-cell responses in HIV controllers but did not adversely affect controller status after ART discontinuation.

Original language	English (US)
Pages (from-to)	1837-1842
Number of pages	6
Journal	Journal of Infectious Diseases
Volume	222
Issue number	11
DOIs	https://doi.org/10.1093/infdis/jiaa294
State	Published - Dec 1 2020
Externally published	Yes

Keywords

HIV controllers
T-cell response
antiretroviral therapy
elite controllers
treatment interruption
viremic control

ASJC Scopus subject areas

General Medicine

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10.1093/infdis/jiaa294

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Jilg, N., Garcia-Broncano, P., Peluso, M., Segal, F. P., Bosch, R. J., Roberts-Toler, C., Chen, S. M. Y., Van Dam, C. N., Keefer, M. C., Kuritzkes, D. R., Landay, A. L., Deeks, S., Yu, X. G., Sax, P. E., & Li, J. Z. (2020). Maintenance of Viral Suppression in Human Immunodeficiency Virus Controllers despite Waning T-Cell Responses during Antiretroviral Therapy. Journal of Infectious Diseases, 222(11), 1837-1842. https://doi.org/10.1093/infdis/jiaa294

Jilg, N, Garcia-Broncano, P, Peluso, M, Segal, FP, Bosch, RJ, Roberts-Toler, C, Chen, SMY, Van Dam, CN, Keefer, MC, Kuritzkes, DR, Landay, AL, Deeks, S, Yu, XG, Sax, PE & Li, JZ 2020, 'Maintenance of Viral Suppression in Human Immunodeficiency Virus Controllers despite Waning T-Cell Responses during Antiretroviral Therapy', Journal of Infectious Diseases, vol. 222, no. 11, pp. 1837-1842. https://doi.org/10.1093/infdis/jiaa294

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title = "Maintenance of Viral Suppression in Human Immunodeficiency Virus Controllers despite Waning T-Cell Responses during Antiretroviral Therapy",

abstract = "AIDS Clinical Trials Group study A5308 found reduced T-cell activation and exhaustion in human immunodeficiency virus (HIV) controllers start antiretroviral therapy (ART). We further assessed HIV-specific T-cell responses and post-ART viral loads. Before ART, the 31% of participants with persistently undetectable viremia had more robust HIV-specific T-cell responses. During ART, significant decreases were observed in a broad range of T-cell responses. Eight controllers in A5308 and the Study of the Consequences of the Protease Inhibitor Era (SCOPE) cohort showed no viremia above the level of quantification in the first 12 weeks after ART discontinuation. ART significantly reduced HIV-specific T-cell responses in HIV controllers but did not adversely affect controller status after ART discontinuation.",

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author = "Nikolaus Jilg and Pilar Garcia-Broncano and Michael Peluso and Segal, {Florencia P.} and Bosch, {Ronald J.} and Carla Roberts-Toler and Chen, {Samantha M.Y.} and {Van Dam}, {Cornelius N.} and Keefer, {Michael C.} and Kuritzkes, {Daniel R.} and Landay, {Alan L.} and Steven Deeks and Yu, {Xu G.} and Sax, {Paul E.} and Li, {Jonathan Z.}",

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AU - Yu, Xu G.

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PY - 2020/12/1

Y1 - 2020/12/1

N2 - AIDS Clinical Trials Group study A5308 found reduced T-cell activation and exhaustion in human immunodeficiency virus (HIV) controllers start antiretroviral therapy (ART). We further assessed HIV-specific T-cell responses and post-ART viral loads. Before ART, the 31% of participants with persistently undetectable viremia had more robust HIV-specific T-cell responses. During ART, significant decreases were observed in a broad range of T-cell responses. Eight controllers in A5308 and the Study of the Consequences of the Protease Inhibitor Era (SCOPE) cohort showed no viremia above the level of quantification in the first 12 weeks after ART discontinuation. ART significantly reduced HIV-specific T-cell responses in HIV controllers but did not adversely affect controller status after ART discontinuation.

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Maintenance of Viral Suppression in Human Immunodeficiency Virus Controllers despite Waning T-Cell Responses during Antiretroviral Therapy

Abstract

Keywords

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