TY - JOUR
T1 - Maguari virus associated with human disease
AU - Groseth, Allison
AU - Vine, Veronica
AU - Weisend, Carla
AU - Guevara, Carolina
AU - Watts, Douglas
AU - Russell, Brandy
AU - Tesh, Robert B.
AU - Ebihara, Hideki
N1 - Publisher Copyright:
© 2017, Centers for Disease Control and Prevention (CDC). All rights reserved.
PY - 2017/8
Y1 - 2017/8
N2 - Despite the lack of evidence for symptomatic human infection with Maguari virus (MAGV), its close relation to Cache Valley virus (CVV), which does infect humans, remains a concern. We sequenced the complete genome of a MAGV-like isolate (OBS6657) obtained from a febrile patient in Pucallpa, Ucayali, Peru, in 1998. To facilitate its classification, we generated additional full-length sequences for the MAGV prototype strain, 3 additional MAGV-like isolates, and the closely related CVV (7 strains), Tlacotalpan (1 strain), Playas (3 strains), and Fort Sherman (1 strain) viruses. The OBS6657 isolate is similar to the MAGV prototype, whereas 2 of the other MAGV-like isolates are located on a distinct branch and most likely warrant classification as a separate virus species and 1 is, in fact, a misclassified CVV strain. Our findings provide clear evidence that MAGV can cause human disease.
AB - Despite the lack of evidence for symptomatic human infection with Maguari virus (MAGV), its close relation to Cache Valley virus (CVV), which does infect humans, remains a concern. We sequenced the complete genome of a MAGV-like isolate (OBS6657) obtained from a febrile patient in Pucallpa, Ucayali, Peru, in 1998. To facilitate its classification, we generated additional full-length sequences for the MAGV prototype strain, 3 additional MAGV-like isolates, and the closely related CVV (7 strains), Tlacotalpan (1 strain), Playas (3 strains), and Fort Sherman (1 strain) viruses. The OBS6657 isolate is similar to the MAGV prototype, whereas 2 of the other MAGV-like isolates are located on a distinct branch and most likely warrant classification as a separate virus species and 1 is, in fact, a misclassified CVV strain. Our findings provide clear evidence that MAGV can cause human disease.
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U2 - 10.3201/eid2308.161254
DO - 10.3201/eid2308.161254
M3 - Article
AN - SCOPUS:85025085390
SN - 1080-6040
VL - 23
SP - 1325
EP - 1331
JO - Emerging infectious diseases
JF - Emerging infectious diseases
IS - 8
ER -