Macrophage physiological function after superparamagnetic iron oxide labeling

Jong Kai Hsiao, Hung Hao Chu, Yu Hsiu Wang, Chih Wei Lai, Pi Tai Chou, Sung Tsang Hsieh, Jaw Lin Wang, Hon Man Liu

Research output: Contribution to journalArticlepeer-review

74 Scopus citations


Our goal was to analyze the changes in morphology and physiological function (phagocytosis, migratory capabilities, humoral and cellular response, and nitric oxide secretion) of murine macrophages after labeling with a clinically used superparamagnetic iron oxide (SPIO), ferucarbotran. In SPIO-treated macrophages, nanoparticles were taken up in the cytoplasm and accumulated in a membrane-bound organelle. Macrophage proliferation and viability were not modified after SPIO labeling. Phagocytic function decreased after labeling with only 10 μg Fe/mL. SPIO, whereas other functions including migration and production of tumor necrosis factor-α and nitric oxide increased at the highest SPIO concentration (100 μg Fe/mL).

Original languageEnglish (US)
Pages (from-to)820-829
Number of pages10
JournalNMR in Biomedicine
Issue number8
StatePublished - Oct 2008
Externally publishedYes


  • Cytokine
  • Iron oxide
  • Migration
  • Phagocytosis
  • Proliferation
  • Rumor necrosis factor
  • Viability

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Spectroscopy


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