Macaque model for severe acute respiratory syndrome

Thomas Rowe; Guangping Gao; Robert J. Hogan; Ronald G. Crystal; Thomas G. Voss; Rebecca L. Grant; Peter Bell; Gary P. Kobinger; Nelson A. Wivel; James M. Wilson

doi:10.1128/JVI.78.20.11401-11404.2004

Macaque model for severe acute respiratory syndrome

Thomas Rowe, Guangping Gao, Robert J. Hogan, Ronald G. Crystal, Thomas G. Voss, Rebecca L. Grant, Peter Bell, Gary P. Kobinger, Nelson A. Wivel, James M. Wilson

Research output: Contribution to journal › Article › peer-review

Abstract

Rhesus and cynomolgus macaques were challenged with 10⁷ PFU of a clinical isolate of the severe acute respiratory syndrome (SARS) coronavirus. Some of the animals developed a mild self-limited respiratory infection very different from that observed in humans with SARS. The macaque model as it currently exists will have limited utility in the study of SARS and the evaluation of therapies.

Original language	English (US)
Pages (from-to)	11401-11404
Number of pages	4
Journal	Journal of virology
Volume	78
Issue number	20
DOIs	https://doi.org/10.1128/JVI.78.20.11401-11404.2004
State	Published - Oct 2004
Externally published	Yes

ASJC Scopus subject areas

Microbiology
Immunology
Insect Science
Virology

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10.1128/JVI.78.20.11401-11404.2004

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title = "Macaque model for severe acute respiratory syndrome",

abstract = "Rhesus and cynomolgus macaques were challenged with 107 PFU of a clinical isolate of the severe acute respiratory syndrome (SARS) coronavirus. Some of the animals developed a mild self-limited respiratory infection very different from that observed in humans with SARS. The macaque model as it currently exists will have limited utility in the study of SARS and the evaluation of therapies.",

author = "Thomas Rowe and Guangping Gao and Hogan, {Robert J.} and Crystal, {Ronald G.} and Voss, {Thomas G.} and Grant, {Rebecca L.} and Peter Bell and Kobinger, {Gary P.} and Wivel, {Nelson A.} and Wilson, {James M.}",

year = "2004",

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doi = "10.1128/JVI.78.20.11401-11404.2004",

language = "English (US)",

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AU - Rowe, Thomas

AU - Gao, Guangping

AU - Hogan, Robert J.

AU - Crystal, Ronald G.

AU - Voss, Thomas G.

AU - Grant, Rebecca L.

AU - Bell, Peter

AU - Kobinger, Gary P.

AU - Wivel, Nelson A.

AU - Wilson, James M.

PY - 2004/10

Y1 - 2004/10

N2 - Rhesus and cynomolgus macaques were challenged with 107 PFU of a clinical isolate of the severe acute respiratory syndrome (SARS) coronavirus. Some of the animals developed a mild self-limited respiratory infection very different from that observed in humans with SARS. The macaque model as it currently exists will have limited utility in the study of SARS and the evaluation of therapies.

AB - Rhesus and cynomolgus macaques were challenged with 107 PFU of a clinical isolate of the severe acute respiratory syndrome (SARS) coronavirus. Some of the animals developed a mild self-limited respiratory infection very different from that observed in humans with SARS. The macaque model as it currently exists will have limited utility in the study of SARS and the evaluation of therapies.

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EP - 11404

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JF - Journal of virology

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ER -

Macaque model for severe acute respiratory syndrome

Abstract

ASJC Scopus subject areas

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