Lymphocyte phenotyping in infants: Maturation of lymphocyte subpopulations and the effects of HIV infection

Kenneth C. Rich, Donald Brambilla, Jane Pitt, Jack Moye, Ellen Cooper, George Hillyer, Hermann Mendez, Mary Glenn Fowler, Alan Landay

Research output: Contribution to journalArticlepeer-review


Changes in the distribution of lymphocyte subpopulations in infants with perinatally acquired HIV infection are confounded by the rapid changes that are the result of normal maturation of the immune system. We describe the changes in seven lymphocyte phenotypes (CD3+CD4+, CD3+CD8+, CD8+HLA-DR+, CD8+CD38+, CD8+CD57+, CD3-/CD16+56+, and CD19+) over the first 2 years of life in 390 HIV-1 exposed but uninfected and 98 HIV-1-infected infants enrolled in the Women and Infants Transmission Study. The greatest changes in uninfected infants were declines in the CD3+CD4+ lymphocytes and increases in CD8+HLA-DR+ and CD19+ lymphocytes. All phenotypes were affected by HIV infection but the greatest changes were declines in the CD3+CD4+ subset and increases in the CD3+CD8+ and CDS+HLA-DR+ subsets. Thus, this study provides reference data for the maturational changes in lymphocyte phenotypes in HIV- exposed but uninfected infants and describes the overall changes that occur with perinatally acquired HIV infection.

Original languageEnglish (US)
Pages (from-to)273-281
Number of pages9
JournalClinical Immunology and Immunopathology
Issue number3
StatePublished - Dec 1997
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology


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