TY - JOUR
T1 - Lymphocyte phenotyping in infants
T2 - Maturation of lymphocyte subpopulations and the effects of HIV infection
AU - Rich, Kenneth C.
AU - Brambilla, Donald
AU - Pitt, Jane
AU - Moye, Jack
AU - Cooper, Ellen
AU - Hillyer, George
AU - Mendez, Hermann
AU - Fowler, Mary Glenn
AU - Landay, Alan
PY - 1997/12
Y1 - 1997/12
N2 - Changes in the distribution of lymphocyte subpopulations in infants with perinatally acquired HIV infection are confounded by the rapid changes that are the result of normal maturation of the immune system. We describe the changes in seven lymphocyte phenotypes (CD3+CD4+, CD3+CD8+, CD8+HLA-DR+, CD8+CD38+, CD8+CD57+, CD3-/CD16+56+, and CD19+) over the first 2 years of life in 390 HIV-1 exposed but uninfected and 98 HIV-1-infected infants enrolled in the Women and Infants Transmission Study. The greatest changes in uninfected infants were declines in the CD3+CD4+ lymphocytes and increases in CD8+HLA-DR+ and CD19+ lymphocytes. All phenotypes were affected by HIV infection but the greatest changes were declines in the CD3+CD4+ subset and increases in the CD3+CD8+ and CDS+HLA-DR+ subsets. Thus, this study provides reference data for the maturational changes in lymphocyte phenotypes in HIV- exposed but uninfected infants and describes the overall changes that occur with perinatally acquired HIV infection.
AB - Changes in the distribution of lymphocyte subpopulations in infants with perinatally acquired HIV infection are confounded by the rapid changes that are the result of normal maturation of the immune system. We describe the changes in seven lymphocyte phenotypes (CD3+CD4+, CD3+CD8+, CD8+HLA-DR+, CD8+CD38+, CD8+CD57+, CD3-/CD16+56+, and CD19+) over the first 2 years of life in 390 HIV-1 exposed but uninfected and 98 HIV-1-infected infants enrolled in the Women and Infants Transmission Study. The greatest changes in uninfected infants were declines in the CD3+CD4+ lymphocytes and increases in CD8+HLA-DR+ and CD19+ lymphocytes. All phenotypes were affected by HIV infection but the greatest changes were declines in the CD3+CD4+ subset and increases in the CD3+CD8+ and CDS+HLA-DR+ subsets. Thus, this study provides reference data for the maturational changes in lymphocyte phenotypes in HIV- exposed but uninfected infants and describes the overall changes that occur with perinatally acquired HIV infection.
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U2 - 10.1006/clin.1997.4439
DO - 10.1006/clin.1997.4439
M3 - Article
C2 - 9400627
AN - SCOPUS:0031393698
SN - 0090-1229
VL - 85
SP - 273
EP - 281
JO - Clinical Immunology and Immunopathology
JF - Clinical Immunology and Immunopathology
IS - 3
ER -