Long‐term colchicine administration leading to colchicine toxicity and death

Michael N. Neuss, Rex M. McCallum, Wayne D. Brenckman, Harold R. Silberman

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


Extracts from the Colchicum autumnale plant have been used to treat gout since the sixth century, and many instances of accidental or intentional overdose have been reported. Although a clinical syndrome due to acute colchicine intoxication is wellknown, we know of no reports of its occurrence while a patient was taking usual prophylactic doses. The following case study may be the first reported example of such an event.

Original languageEnglish (US)
Pages (from-to)448-449
Number of pages2
JournalArthritis & Rheumatism
Issue number3
StatePublished - Mar 1986
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)


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