Longitudinal assessment of coronary plaque volume change related to glycemic status using serial coronary computed tomography angiography: A PARADIGM (Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography Imaging)substudy

Ki Bum Won; Sang Eun Lee; Byoung Kwon Lee; Hyung Bok Park; Ran Heo; Asim Rizvi; Fay Y. Lin; Amit Kumar; Martin Hadamitzky; Yong Jin Kim; Ji Min Sung; Edoardo Conte; Daniele Andreini; Gianluca Pontone; Matthew J. Budoff; Ilan Gottlieb; Eun Ju Chun; Filippo Cademartiri; Erica Maffei; Hugo Marques; Jonathon A. Leipsic; Sanghoon Shin; Jung Hyun Choi; Renu Virmani; Habib Samady; Kavitha Chinnaiyan; Gilbert L. Raff; Peter H. Stone; Daniel S. Berman; Jagat Narula; Leslee J. Shaw; Jeroen J. Bax; James K. Min; Hyuk Jae Chang

doi:10.1016/j.jcct.2018.12.002

Longitudinal assessment of coronary plaque volume change related to glycemic status using serial coronary computed tomography angiography: A PARADIGM (Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography Imaging)substudy

Ki Bum Won, Sang Eun Lee, Byoung Kwon Lee, Hyung Bok Park, Ran Heo, Asim Rizvi, Fay Y. Lin, Amit Kumar, Martin Hadamitzky, Yong Jin Kim, Ji Min Sung, Edoardo Conte, Daniele Andreini, Gianluca Pontone, Matthew J. Budoff, Ilan Gottlieb, Eun Ju Chun, Filippo Cademartiri, Erica Maffei, Hugo MarquesJonathon A. Leipsic, Sanghoon Shin, Jung Hyun Choi, Renu Virmani, Habib Samady, Kavitha Chinnaiyan, Gilbert L. Raff, Peter H. Stone, Daniel S. Berman, Jagat Narula, Leslee J. Shaw, Jeroen J. Bax, James K. Min, Hyuk Jae Chang

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Data on the impact of glycemic status on coronary plaque progression have been limited. This study evaluated the association between glycemic status and coronary plaque volume change (PVC)using coronary computed tomography angiography (CCTA). Methods: A total of 1296 subjects (61 ± 9, 56.9% male)who underwent serial CCTA with available glycemic status were enrolled and analyzed from the Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM)registry. The median inter-scan period was 3.2 (2.6–4.4)years. Quantitative assessment of coronary plaques was performed at both scans. All participants were categorized into the following groups according to glycemic status: normal, pre-diabetes (pre-DM), and diabetes mellitus (DM). Results: During the follow-up, significant differences in PVC (normal: 51.3 ± 83.3 mm³ vs. pre-DM: 51.0 ± 84.3 mm³ vs. DM: 72.6 ± 95.0 mm³; p < 0.001)and annualized PVC (normal: 14.9 ± 24.9 mm³ vs. pre-DM: 15.7 ± 23.8 mm³ vs. DM: 21.0 ± 27.7 mm³; p = 0.001)were observed among the 3 groups. Compared with normal individuals, individuals with pre-DM showed no significant differences in the adjusted odds ratio (OR)for plaque progression (PP)(1.338, 95% confidence interval [CI]0.967–1.853; p = 0.079). However, the adjusted OR for PP was higher in DM individuals than in normal individuals (1.635, 95% CI 1.126–2.375; p = 0.010). Conclusion: DM had an incremental impact on coronary PP, but pre-DM appeared to have no significant association with an increased risk of coronary PP after adjusting for confounding factors. Clinical trial registration: ClinicalTrials.gov NCT02803411.

Original language	English (US)
Pages (from-to)	142-147
Number of pages	6
Journal	Journal of Cardiovascular Computed Tomography
Volume	13
Issue number	2
DOIs	https://doi.org/10.1016/j.jcct.2018.12.002
State	Published - Mar 1 2019
Externally published	Yes

Keywords

Coronary atherosclerosis
Coronary computed tomography angiography
Pre-diabetes

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Cardiology and Cardiovascular Medicine

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Won, K. B., Lee, S. E., Lee, B. K., Park, H. B., Heo, R., Rizvi, A., Lin, F. Y., Kumar, A., Hadamitzky, M., Kim, Y. J., Sung, J. M., Conte, E., Andreini, D., Pontone, G., Budoff, M. J., Gottlieb, I., Chun, E. J., Cademartiri, F., Maffei, E., ... Chang, H. J. (2019). Longitudinal assessment of coronary plaque volume change related to glycemic status using serial coronary computed tomography angiography: A PARADIGM (Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography Imaging)substudy. Journal of Cardiovascular Computed Tomography, 13(2), 142-147. https://doi.org/10.1016/j.jcct.2018.12.002

Longitudinal assessment of coronary plaque volume change related to glycemic status using serial coronary computed tomography angiography: A PARADIGM (Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography Imaging)substudy. / Won, Ki Bum; Lee, Sang Eun; Lee, Byoung Kwon et al.
In: Journal of Cardiovascular Computed Tomography, Vol. 13, No. 2, 01.03.2019, p. 142-147.

Research output: Contribution to journal › Article › peer-review

Won, KB, Lee, SE, Lee, BK, Park, HB, Heo, R, Rizvi, A, Lin, FY, Kumar, A, Hadamitzky, M, Kim, YJ, Sung, JM, Conte, E, Andreini, D, Pontone, G, Budoff, MJ, Gottlieb, I, Chun, EJ, Cademartiri, F, Maffei, E, Marques, H, Leipsic, JA, Shin, S, Choi, JH, Virmani, R, Samady, H, Chinnaiyan, K, Raff, GL, Stone, PH, Berman, DS, Narula, J, Shaw, LJ, Bax, JJ, Min, JK & Chang, HJ 2019, 'Longitudinal assessment of coronary plaque volume change related to glycemic status using serial coronary computed tomography angiography: A PARADIGM (Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography Imaging)substudy', Journal of Cardiovascular Computed Tomography, vol. 13, no. 2, pp. 142-147. https://doi.org/10.1016/j.jcct.2018.12.002

Won KB, Lee SE, Lee BK, Park HB, Heo R, Rizvi A et al. Longitudinal assessment of coronary plaque volume change related to glycemic status using serial coronary computed tomography angiography: A PARADIGM (Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography Imaging)substudy. Journal of Cardiovascular Computed Tomography. 2019 Mar 1;13(2):142-147. doi: 10.1016/j.jcct.2018.12.002

Won, Ki Bum ; Lee, Sang Eun ; Lee, Byoung Kwon et al. / Longitudinal assessment of coronary plaque volume change related to glycemic status using serial coronary computed tomography angiography : A PARADIGM (Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography Imaging)substudy. In: Journal of Cardiovascular Computed Tomography. 2019 ; Vol. 13, No. 2. pp. 142-147.

@article{ee8a7abc0fcb4e4db8afb362fc5c3ba6,

title = "Longitudinal assessment of coronary plaque volume change related to glycemic status using serial coronary computed tomography angiography: A PARADIGM (Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography Imaging)substudy",

abstract = "Background: Data on the impact of glycemic status on coronary plaque progression have been limited. This study evaluated the association between glycemic status and coronary plaque volume change (PVC)using coronary computed tomography angiography (CCTA). Methods: A total of 1296 subjects (61 ± 9, 56.9% male)who underwent serial CCTA with available glycemic status were enrolled and analyzed from the Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM)registry. The median inter-scan period was 3.2 (2.6–4.4)years. Quantitative assessment of coronary plaques was performed at both scans. All participants were categorized into the following groups according to glycemic status: normal, pre-diabetes (pre-DM), and diabetes mellitus (DM). Results: During the follow-up, significant differences in PVC (normal: 51.3 ± 83.3 mm3 vs. pre-DM: 51.0 ± 84.3 mm3 vs. DM: 72.6 ± 95.0 mm3; p < 0.001)and annualized PVC (normal: 14.9 ± 24.9 mm3 vs. pre-DM: 15.7 ± 23.8 mm3 vs. DM: 21.0 ± 27.7 mm3; p = 0.001)were observed among the 3 groups. Compared with normal individuals, individuals with pre-DM showed no significant differences in the adjusted odds ratio (OR)for plaque progression (PP)(1.338, 95% confidence interval [CI]0.967–1.853; p = 0.079). However, the adjusted OR for PP was higher in DM individuals than in normal individuals (1.635, 95% CI 1.126–2.375; p = 0.010). Conclusion: DM had an incremental impact on coronary PP, but pre-DM appeared to have no significant association with an increased risk of coronary PP after adjusting for confounding factors. Clinical trial registration: ClinicalTrials.gov NCT02803411.",

keywords = "Coronary atherosclerosis, Coronary computed tomography angiography, Pre-diabetes",

author = "Won, {Ki Bum} and Lee, {Sang Eun} and Lee, {Byoung Kwon} and Park, {Hyung Bok} and Ran Heo and Asim Rizvi and Lin, {Fay Y.} and Amit Kumar and Martin Hadamitzky and Kim, {Yong Jin} and Sung, {Ji Min} and Edoardo Conte and Daniele Andreini and Gianluca Pontone and Budoff, {Matthew J.} and Ilan Gottlieb and Chun, {Eun Ju} and Filippo Cademartiri and Erica Maffei and Hugo Marques and Leipsic, {Jonathon A.} and Sanghoon Shin and Choi, {Jung Hyun} and Renu Virmani and Habib Samady and Kavitha Chinnaiyan and Raff, {Gilbert L.} and Stone, {Peter H.} and Berman, {Daniel S.} and Jagat Narula and Shaw, {Leslee J.} and Bax, {Jeroen J.} and Min, {James K.} and Chang, {Hyuk Jae}",

note = "Publisher Copyright: {\textcopyright} 2018",

year = "2019",

month = mar,

day = "1",

doi = "10.1016/j.jcct.2018.12.002",

language = "English (US)",

volume = "13",

pages = "142--147",

journal = "Journal of Cardiovascular Computed Tomography",

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TY - JOUR

T1 - Longitudinal assessment of coronary plaque volume change related to glycemic status using serial coronary computed tomography angiography

T2 - A PARADIGM (Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography Imaging)substudy

AU - Won, Ki Bum

AU - Lee, Sang Eun

AU - Lee, Byoung Kwon

AU - Park, Hyung Bok

AU - Heo, Ran

AU - Rizvi, Asim

AU - Lin, Fay Y.

AU - Kumar, Amit

AU - Hadamitzky, Martin

AU - Kim, Yong Jin

AU - Sung, Ji Min

AU - Conte, Edoardo

AU - Andreini, Daniele

AU - Pontone, Gianluca

AU - Budoff, Matthew J.

AU - Gottlieb, Ilan

AU - Chun, Eun Ju

AU - Cademartiri, Filippo

AU - Maffei, Erica

AU - Marques, Hugo

AU - Leipsic, Jonathon A.

AU - Shin, Sanghoon

AU - Choi, Jung Hyun

AU - Virmani, Renu

AU - Samady, Habib

AU - Chinnaiyan, Kavitha

AU - Raff, Gilbert L.

AU - Stone, Peter H.

AU - Berman, Daniel S.

AU - Narula, Jagat

AU - Shaw, Leslee J.

AU - Bax, Jeroen J.

AU - Min, James K.

AU - Chang, Hyuk Jae

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Background: Data on the impact of glycemic status on coronary plaque progression have been limited. This study evaluated the association between glycemic status and coronary plaque volume change (PVC)using coronary computed tomography angiography (CCTA). Methods: A total of 1296 subjects (61 ± 9, 56.9% male)who underwent serial CCTA with available glycemic status were enrolled and analyzed from the Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM)registry. The median inter-scan period was 3.2 (2.6–4.4)years. Quantitative assessment of coronary plaques was performed at both scans. All participants were categorized into the following groups according to glycemic status: normal, pre-diabetes (pre-DM), and diabetes mellitus (DM). Results: During the follow-up, significant differences in PVC (normal: 51.3 ± 83.3 mm3 vs. pre-DM: 51.0 ± 84.3 mm3 vs. DM: 72.6 ± 95.0 mm3; p < 0.001)and annualized PVC (normal: 14.9 ± 24.9 mm3 vs. pre-DM: 15.7 ± 23.8 mm3 vs. DM: 21.0 ± 27.7 mm3; p = 0.001)were observed among the 3 groups. Compared with normal individuals, individuals with pre-DM showed no significant differences in the adjusted odds ratio (OR)for plaque progression (PP)(1.338, 95% confidence interval [CI]0.967–1.853; p = 0.079). However, the adjusted OR for PP was higher in DM individuals than in normal individuals (1.635, 95% CI 1.126–2.375; p = 0.010). Conclusion: DM had an incremental impact on coronary PP, but pre-DM appeared to have no significant association with an increased risk of coronary PP after adjusting for confounding factors. Clinical trial registration: ClinicalTrials.gov NCT02803411.

AB - Background: Data on the impact of glycemic status on coronary plaque progression have been limited. This study evaluated the association between glycemic status and coronary plaque volume change (PVC)using coronary computed tomography angiography (CCTA). Methods: A total of 1296 subjects (61 ± 9, 56.9% male)who underwent serial CCTA with available glycemic status were enrolled and analyzed from the Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM)registry. The median inter-scan period was 3.2 (2.6–4.4)years. Quantitative assessment of coronary plaques was performed at both scans. All participants were categorized into the following groups according to glycemic status: normal, pre-diabetes (pre-DM), and diabetes mellitus (DM). Results: During the follow-up, significant differences in PVC (normal: 51.3 ± 83.3 mm3 vs. pre-DM: 51.0 ± 84.3 mm3 vs. DM: 72.6 ± 95.0 mm3; p < 0.001)and annualized PVC (normal: 14.9 ± 24.9 mm3 vs. pre-DM: 15.7 ± 23.8 mm3 vs. DM: 21.0 ± 27.7 mm3; p = 0.001)were observed among the 3 groups. Compared with normal individuals, individuals with pre-DM showed no significant differences in the adjusted odds ratio (OR)for plaque progression (PP)(1.338, 95% confidence interval [CI]0.967–1.853; p = 0.079). However, the adjusted OR for PP was higher in DM individuals than in normal individuals (1.635, 95% CI 1.126–2.375; p = 0.010). Conclusion: DM had an incremental impact on coronary PP, but pre-DM appeared to have no significant association with an increased risk of coronary PP after adjusting for confounding factors. Clinical trial registration: ClinicalTrials.gov NCT02803411.

KW - Coronary atherosclerosis

KW - Coronary computed tomography angiography

KW - Pre-diabetes

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VL - 13

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JO - Journal of Cardiovascular Computed Tomography

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Longitudinal assessment of coronary plaque volume change related to glycemic status using serial coronary computed tomography angiography: A PARADIGM (Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography Imaging)substudy

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Keywords

ASJC Scopus subject areas

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