TY - JOUR
T1 - Local heat urticaria/angioedema
T2 - Evidence for histamine release without complement activation
AU - Grant, J. Andrew
AU - Findlay, Steven R.
AU - Thueson, David O.
AU - Fine, Douglas P.
AU - Krueger, Gerald G.
N1 - Funding Information:
From the Departmenrs of Internal Medicine of the University of Texas Medical Branch a1 Galveston and of the University of Utah Medical Center. Suppuned in part by U.S. Public Health Service Research Grant AI-1262 I and General Clinical Research Programs grants RR-64 and RR-73. Recc:ved for publication April 30, 1980. Accelwed for publication Sept. 26, 1980. Reprint requests to: J. Andrew Grant, M.D.. The University of Texas Medical Branch, Department of Internal Medicine. Al-lerw Division. Clinical Sciences 405, Galveston, TX 77550. *Recipint of Allergic Diseases Academic Award AI-001 IO. **Recipient of a James B. McLaughlin Fellowship Grant. ***Recipient of Young Investigator Award AI-14879 from the Na-tional Institutes of Health.
PY - 1981/1
Y1 - 1981/1
N2 - A 42-yr-old white woman reported onset in 1976 of local pruritus, burning, erythema, and edema within minutes after exposure to heat. With more extensive exposure, she occasionally had transient headaches and nausea. In order to investigate the etiology of this condition, her forearm was exposed to water at 44 °C for 4 min. Within a few minutes, a lesion identical to her spontaneously induced ones developed only at the area exposed to heat. Samples of venous blood from this extremity demonstrated a transient rise in plasma histamine levels without any significant change in serum hemolytic complement activity or in C3, C4, or factor B. These findings suggest that this rare syndrome involves local activation of mediator release from mast cells, without participation of the complement system.
AB - A 42-yr-old white woman reported onset in 1976 of local pruritus, burning, erythema, and edema within minutes after exposure to heat. With more extensive exposure, she occasionally had transient headaches and nausea. In order to investigate the etiology of this condition, her forearm was exposed to water at 44 °C for 4 min. Within a few minutes, a lesion identical to her spontaneously induced ones developed only at the area exposed to heat. Samples of venous blood from this extremity demonstrated a transient rise in plasma histamine levels without any significant change in serum hemolytic complement activity or in C3, C4, or factor B. These findings suggest that this rare syndrome involves local activation of mediator release from mast cells, without participation of the complement system.
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U2 - 10.1016/0091-6749(81)90049-X
DO - 10.1016/0091-6749(81)90049-X
M3 - Article
C2 - 6161144
AN - SCOPUS:0019491395
SN - 0091-6749
VL - 67
SP - 75
EP - 77
JO - The Journal of Allergy and Clinical Immunology
JF - The Journal of Allergy and Clinical Immunology
IS - 1
ER -