Leiomyosarcoma in a Renal Allograft Recipient Treated With Immunosuppressive Drugs

David Walker, Thomas J. Gill, J. Mackie Corson

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


A highly malignant gastric leiomyosarcoma developed in a renal allograft recipient. This was the first primary malignant tumor observed in 247 patients at the Peter Bent Brigham Hospital who received immunosuppressive therapy following renal transplantation. Among the 3,614 patients listed in the Human Kidney Transplant Registry as receiving allografts, 37 primary malignant tumors have been reported. This incidence of malignancy is 4.7 times greater than expected. Examination of the therapy employed in the 37 cases suggests that azathioprine is a major factor in the development of the tumors and that prednisone may act in a subsidiary role by suppressing the cellular immune response.

Original languageEnglish (US)
Pages (from-to)2084-2086
Number of pages3
JournalJAMA: The Journal of the American Medical Association
Issue number13
StatePublished - Mar 29 1971
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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