Latin American Trans-ancestry INitiative for OCD genomics (LATINO): Study protocol

James J. Crowley, Carolina Cappi, Marcos E. Ochoa-Panaifo, Renee M. Frederick, Minjee Kook, Andrew D. Wiese, Diana Rancourt, Elizabeth G. Atkinson, Paola Giusti-Rodriguez, Jacey L. Anderberg, Jonathan S. Abramowitz, Victor R. Adorno, Cinthia Aguirre, Gilberto S. Alves, Gustavo S. Alves, Na Eshia Ancalade, Alejandro A. Arellano Espinosa, Paul D. Arnold, Daphne M. Ayton, Izabela G. BarbosaLaura Marcela Barón Castano, Cynthia N. Barrera, María Celeste Berardo, Dayan Berrones, John R. Best, Tim B. Bigdeli, Christie L. Burton, Joseph D. Buxbaum, Jennifer L. Callahan, Maria Cecília B. Carneiro, Sandra L. Cepeda, Evelyn Chazelle, Jessica M. Chire, Macarena Churruca Munoz, Pamela Claisse Quiroz, Journa Cobite, Jonathan S. Comer, Daniel L. Costa, Jennifer Crosbie, Victor O. Cruz, Guillermo Dager, Luisa F. Daza, Anabel de la Rosa-Gómez, Daniela del Río, Fernanda Z. Delage, Carolina B. Dreher, Lucila Fay, Tomas Fazio, Ygor A. Ferrão, Gabriela M. Ferreira, Edith G. Figueroa, Leonardo F. Fontenelle, Diego A. Forero, Daniele T.H. Fragoso, Bharathi S. Gadad, Sheldon R. Garrison, Andres González, Laura D. Gonzalez, Marco A. González, Polaris Gonzalez-Barrios, Wayne K. Goodman, Dorothy E. Grice, Jerry Guintivano, Daniel G. Guttfreund, Andrew G. Guzick, Matthew W. Halvorsen, Joseph D. Hovey, Hailiang Huang, Jonathan Irreño-Sotomonte, Reinhard Janssen-Aguilar, Matias Jensen, Alexandra Z. Jimenez Reynolds, Joali Alexandra Juárez Lujambio, Nasim Khalfe, Madison A. Knutsen, Caleb Lack, Nuria Lanzagorta, Monicke O. Lima, Melanie O. Longhurst, David A. Lozada Martinez, Elba S. Luna, Andrea H. Marques, Molly S. Martinez, Maria de Los Angeles Matos, Caitlyn E. Maye, Joseph F. McGuire, Gabriela Menezes, Charlene Minaya, Tomás Miño, Sara M. Mithani, Circe Montes de Oca, Alonso Morales-Rivero, Maria E. Moreira-de-Oliveira, Olivia J. Morris, Sandra I. Muñoz, Zainab Naqqash, Ambar A. Núñez Bracho, Belinda E. Núñez Bracho, Maria Corina Ochoa Rojas, Luis A. Olavarria Castaman, Trinidad Olivos Balmaceda, Iliana Ortega, Darpan I. Patel, Ainsley K. Patrick, Mariel Paz y Mino, Jose L. Perales Orellana, Bárbara Perdigão Stumpf, Tamara Peregrina, Tania Pérez Duarte, Kelly L. Piacsek, Maritza Placencia, María Belén Prieto, Lucas C. Quarantini, Yana Quarantini-Alvim, Renato T. Ramos, Iaroslava C. Ramos, Vanessa R. Ramos, Kesley A. Ramsey, Elise V. Ray, Margaret A. Richter, Bradley C. Riemann, Juan C. Rivas, Maria C. Rosario, Camilo J. Ruggero, Angel A. Ruiz-Chow, Alejandra Ruiz-Velasco, Melisa N. Sagarnaga, Aline S. Sampaio, Leonardo C. Saraiva, Russell J. Schachar, Sophie C. Schneider, Ethan J. Schweissing, Laura D. Seligman, Roseli G. Shavitt, Keaton J. Soileau, S. Evelyn Stewart, Shaina B. Storch, Emily R. Strouphauer, Vissente Tapia Cuevas, Kiara R. Timpano, Beatriz Treviño de la Garza, Alexie Vallejo-Silva, Javier Vargas-Medrano, María I. Vásquez, Guadalupe Vidal Martinez, Saira A. Weinzimmer, Mauricio A. Yanez, Gwyneth Zai, Lina M. Zapata-Restrepo, Luz M. Zappa, Raquel M. Zepeda-Burgos, Anthony W. Zoghbi, Euripedes C. Miguel, Carolyn I. Rodriguez, Mayra C. Martinez Mallen, Pablo R. Moya, Tania Borda, María Beatriz Moyano, Manuel Mattheisen, Stacey Pereira, Gabriel Lázaro-Muñoz, Karen G. Martinez-Gonzalez, Michele T. Pato, Humberto Nicolini, Eric A. Storch

Research output: Contribution to journalArticlepeer-review

Abstract

Obsessive-compulsive disorder (OCD) is a debilitating psychiatric disorder. Worldwide, its prevalence is ~2% and its etiology is mostly unknown. Identifying biological factors contributing to OCD will elucidate underlying mechanisms and might contribute to improved treatment outcomes. Genomic studies of OCD are beginning to reveal long-sought risk loci, but >95% of the cases currently in analysis are of homogenous European ancestry. If not addressed, this Eurocentric bias will result in OCD genomic findings being more accurate for individuals of European ancestry than other ancestries, thereby contributing to health disparities in potential future applications of genomics. In this study protocol paper, we describe the Latin American Trans-ancestry INitiative for OCD genomics (LATINO, https://www.latinostudy.org). LATINO is a new network of investigators from across Latin America, the United States, and Canada who have begun to collect DNA and clinical data from 5000 richly phenotyped OCD cases of Latin American ancestry in a culturally sensitive and ethical manner. In this project, we will utilize trans-ancestry genomic analyses to accelerate the identification of OCD risk loci, fine-map putative causal variants, and improve the performance of polygenic risk scores in diverse populations. We will also capitalize on rich clinical data to examine the genetics of treatment response, biologically plausible OCD subtypes, and symptom dimensions. Additionally, LATINO will help elucidate the diversity of the clinical presentations of OCD across cultures through various trainings developed and offered in collaboration with Latin American investigators. We believe this study will advance the important goal of global mental health discovery and equity.

Original languageEnglish (US)
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
DOIs
StateAccepted/In press - 2023
Externally publishedYes

Keywords

  • GWAS
  • Latin American
  • OCD
  • genetic
  • genomic
  • obsessive-compulsive disorder

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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