TY - JOUR
T1 - Latent tuberculosis infection and non-infectious co-morbidities
T2 - Diabetes mellitus type 2, chronic kidney disease and rheumatoid arthritis
AU - Ugarte-Gil, Cesar
AU - Carrillo-Larco, Rodrigo M.
AU - Kirwan, Daniela E.
N1 - Publisher Copyright:
© 2019 The Authors
PY - 2019/3
Y1 - 2019/3
N2 - The prevalence of non-communicable diseases is increasing worldwide, which coincides with the persistence of infectious diseases including tuberculosis. These can synergistically affect individual and population health. Three non-communicable diseases that are relevant because of their associated morbidity, mortality and disability are type 2 diabetes mellitus, chronic kidney disease and rheumatoid arthritis. There is some evidence that patients with these conditions are at increased risk of acquiring latent tuberculosis infection (LTBI) and of this progressing to active disease. Unfortunately, evidence on accurate testing and effective prophylactic treatment in these populations is lacking. This review discusses current evidence and recommendations for management of LTBI in these patients.
AB - The prevalence of non-communicable diseases is increasing worldwide, which coincides with the persistence of infectious diseases including tuberculosis. These can synergistically affect individual and population health. Three non-communicable diseases that are relevant because of their associated morbidity, mortality and disability are type 2 diabetes mellitus, chronic kidney disease and rheumatoid arthritis. There is some evidence that patients with these conditions are at increased risk of acquiring latent tuberculosis infection (LTBI) and of this progressing to active disease. Unfortunately, evidence on accurate testing and effective prophylactic treatment in these populations is lacking. This review discusses current evidence and recommendations for management of LTBI in these patients.
KW - Chronic kidney disease and Rheumatoid arthritis
KW - Diabetes mellitus type 2
KW - Tuberculosis
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U2 - 10.1016/j.ijid.2019.02.018
DO - 10.1016/j.ijid.2019.02.018
M3 - Article
C2 - 30802622
AN - SCOPUS:85062173537
SN - 1201-9712
VL - 80
SP - S29-S31
JO - International Journal of Infectious Diseases
JF - International Journal of Infectious Diseases
ER -