Late sequelae of treated pleomorphic xanthoastrocytoma: Malignant brain stem astrocytoma occurring 15 years after radiation therapy

Gregory N. Fuller, Samer E. Kaba, Lawrence E. Ginsberg, Ian E. McCutcheon, Lauren A. Langford

Research output: Contribution to journalArticlepeer-review

Abstract

The pleomorphic xanthoastrocytoma (PXA) is a unique astrocytic neoplasm with an unexpectedly favorable prognosis despite striking pleomorphism of the cellular constituents. Although a majority of patients experience extended survival, these tumors may recur and some cases progress to high-grade astrocytoma. Recurrence inevitably involves the anatomic vicinity of the primary tumor. In this report, we describe a malignant brain stem astrocytoma that occurred 15 years after surgery and radiation treatment of a 16-year-old patient who had a temporal lobe PXA. To our knowledge, this is the first reported case of a malignant astrocytoma arising outside the primary anatomic site of a previously treated PXA and likely represents a radiation-induced secondary neoplasm.

Original languageEnglish (US)
Pages (from-to)57-61
Number of pages5
JournalJournal of Neuro-Oncology
Volume32
Issue number1
DOIs
StatePublished - 1997
Externally publishedYes

Keywords

  • Brain stem astrocytoma
  • Pleomorphic xanthoastrocytoma
  • Radiation therapy
  • Trigeminal neuralgia

ASJC Scopus subject areas

  • Oncology
  • Neurology
  • Clinical Neurology
  • Cancer Research

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