Laser-tissue interaction during transmyocardial laser revascularization

E. Duco Jansen, Martin Frenz, Kamuran A. Kadipasaoglu, T. Joshua Pfefer, Hans J. Altermatt, Massoud Motamedi, Ashley J. Welch

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations


The clinical procedure known as transmyocardial revascularization has recently seen its renaissance. Despite the promising preliminary clinical results, the associated mechanisms are subject to much discussion. This study is an attempt to unravel the basics of the interaction between 800 W carbon-dioxide laser radiation and biological tissue. Time-resolved flash photography was used to visualize the laser-induced channel formation in water and tissue phantoms. In addition laser-induced pressures were measured. Channel depth was shown to increase logarithmically with time (i.e. with pulse duration) in water, tissue phantoms and porcine myocardium. Pressure measurements show numerous small transients during the laser pulse which corresponded to the local and partial collapse of the formed channel already during the pulse. It was shown that in tissue, 20 mm of myocardium is perforated in 25 ms. Increasing the pulse duration only has a small effect on the maximum transversible thickness while histology shows that thermal damage around the crater increased with increasing pulse duration.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsR.Rox Anderson
Number of pages9
StatePublished - 1996
Externally publishedYes
EventLasers in Surgery: Advanced Characterization, Therapeutics, and Systems VI - San Jose, CA, USA
Duration: Jan 27 1996Jan 30 1996

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering


OtherLasers in Surgery: Advanced Characterization, Therapeutics, and Systems VI
CitySan Jose, CA, USA

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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