Laboratory evaluation of hypercoagulable states

E. M. Van Cott, M. Laposata

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


The number of well-characterized hereditary and acquired hypercoagulable conditions is increasing, such that in many thrombophilic patients, the laboratory can now identify a hypercoagulable condition. This review describes the currently known hypercoagulable states that predispose patients to venous, and in some instances, arterial thrombosis. For each condition, the discussion includes the incidence, magnitude of the thrombotic risk in the general population in comparison with symptomatic families, synergistic interactions among the various hypercoagulable conditions, molecular pathogenesis, and interpretation of laboratory test results. In addition, recommendations for laboratory testing are summarized.

Original languageEnglish (US)
Pages (from-to)1141-1166
Number of pages26
JournalHematology/Oncology Clinics of North America
Issue number6
StatePublished - 1998
Externally publishedYes

ASJC Scopus subject areas

  • Hematology
  • Oncology


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