L-threodops increases extracellular norepinephrine levels in the brain: An in vivo study

Timothy Brannan; Anish Bhardwaj; Melvin D. Yahr

doi:10.1212/wnl.40.7.1134

L-threodops increases extracellular norepinephrine levels in the brain: An in vivo study

Timothy Brannan, Anish Bhardwaj, Melvin D. Yahr

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Extracellular norepinephrine levels in the striatum of normal rats increased significantly following the administration of L-threodops. When peripheral decarboxylase activity was inhibited with carbidopa, administration of the same dose of L-threodops induced a 2.5-fold greater increase in norepinephrine levels.

Original language	English (US)
Pages (from-to)	1134-1135
Number of pages	2
Journal	Neurology
Volume	40
Issue number	7
DOIs	https://doi.org/10.1212/wnl.40.7.1134
State	Published - Jul 1990
Externally published	Yes

ASJC Scopus subject areas

Clinical Neurology

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10.1212/wnl.40.7.1134

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title = "L-threodops increases extracellular norepinephrine levels in the brain: An in vivo study",

abstract = "Extracellular norepinephrine levels in the striatum of normal rats increased significantly following the administration of L-threodops. When peripheral decarboxylase activity was inhibited with carbidopa, administration of the same dose of L-threodops induced a 2.5-fold greater increase in norepinephrine levels.",

author = "Timothy Brannan and Anish Bhardwaj and Yahr, {Melvin D.}",

year = "1990",

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doi = "10.1212/wnl.40.7.1134",

language = "English (US)",

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AU - Bhardwaj, Anish

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AB - Extracellular norepinephrine levels in the striatum of normal rats increased significantly following the administration of L-threodops. When peripheral decarboxylase activity was inhibited with carbidopa, administration of the same dose of L-threodops induced a 2.5-fold greater increase in norepinephrine levels.

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L-threodops increases extracellular norepinephrine levels in the brain: An in vivo study

Abstract

ASJC Scopus subject areas

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