Kinesin: possible biological roles for a new microtubule motor

Ronald D. Vale; Jonathan M. Scholey; Michael P. Sheetz

doi:10.1016/0968-0004(86)90248-3

Kinesin: possible biological roles for a new microtubule motor

Ronald D. Vale, Jonathan M. Scholey, Michael P. Sheetz

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

Organelle transport along microtubules can be reconstituted using isolated components, allowing this complex motility process to be dissected biochemically. This approach has led to the purification of a novel and ubiquitous microtubule-based, force-generating protein named kinesin. The in vitro motile properties and immunocytochemical localization of kinesin suggest that it may serve as a motor for organelle transport and for microtubule-based movements during mitosis.

Original language	English (US)
Pages (from-to)	464-468
Number of pages	5
Journal	Trends in biochemical sciences
Volume	11
Issue number	11
DOIs	https://doi.org/10.1016/0968-0004(86)90248-3
State	Published - Nov 1986
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Biochemistry

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10.1016/0968-0004(86)90248-3

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abstract = "Organelle transport along microtubules can be reconstituted using isolated components, allowing this complex motility process to be dissected biochemically. This approach has led to the purification of a novel and ubiquitous microtubule-based, force-generating protein named kinesin. The in vitro motile properties and immunocytochemical localization of kinesin suggest that it may serve as a motor for organelle transport and for microtubule-based movements during mitosis.",

author = "Vale, {Ronald D.} and Scholey, {Jonathan M.} and Sheetz, {Michael P.}",

year = "1986",

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AU - Scholey, Jonathan M.

AU - Sheetz, Michael P.

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AB - Organelle transport along microtubules can be reconstituted using isolated components, allowing this complex motility process to be dissected biochemically. This approach has led to the purification of a novel and ubiquitous microtubule-based, force-generating protein named kinesin. The in vitro motile properties and immunocytochemical localization of kinesin suggest that it may serve as a motor for organelle transport and for microtubule-based movements during mitosis.

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Kinesin: possible biological roles for a new microtubule motor

Abstract

ASJC Scopus subject areas

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