Kidney diseases associated with Waldenström macroglobulinemia

Nupur N. Uppal; Divya Monga; Melchiore A. Vernace; Khurram Mehtabdin; Hitesh H. Shah; Vanesa Bijol; Kenar D. Jhaveri

doi:10.1093/ndt/gfy320

Kidney diseases associated with Waldenström macroglobulinemia

Nupur N. Uppal, Divya Monga, Melchiore A. Vernace, Khurram Mehtabdin, Hitesh H. Shah, Vanesa Bijol, Kenar D. Jhaveri

Research output: Contribution to journal › Review article › peer-review

Abstract

Waldenström macroglobulinemia (WM) is a rare B-cell lymphoma characterized by lymphoplasmacytic cell infiltration in the bone marrow and other organs and the presence of a monoclonal immunoglobulin M protein in the serum. Although uncommon, several kidney diseases have been associated with WM. In addition to kidney diseases related to lymphoplasmacytic lymphoma infiltration, a variety of glomerular and tubular lesions have been described in patients with WM. Immunoglobulin light chain (AL) amyloidosis and cryoglobulinemic glomerulonephritis are the two predominant glomerular pathologies seen in WM. In this article we review the kidney diseases associated with WM. We also briefly review some nephrotoxicities of novel chemotherapeutic and targeted therapies used for the treatment of WM.

Original language	English (US)
Pages (from-to)	1644-1652
Number of pages	9
Journal	Nephrology Dialysis Transplantation
Volume	34
Issue number	10
DOIs	https://doi.org/10.1093/ndt/gfy320
State	Published - Oct 1 2019
Externally published	Yes

Keywords

MPGN
Waldenström macroglobulinemia
amyloidosis
onconephrology
paraproteinemia

ASJC Scopus subject areas

Nephrology
Transplantation

Access to Document

10.1093/ndt/gfy320

Cite this

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title = "Kidney diseases associated with Waldenstr{\"o}m macroglobulinemia",

abstract = "Waldenstr{\"o}m macroglobulinemia (WM) is a rare B-cell lymphoma characterized by lymphoplasmacytic cell infiltration in the bone marrow and other organs and the presence of a monoclonal immunoglobulin M protein in the serum. Although uncommon, several kidney diseases have been associated with WM. In addition to kidney diseases related to lymphoplasmacytic lymphoma infiltration, a variety of glomerular and tubular lesions have been described in patients with WM. Immunoglobulin light chain (AL) amyloidosis and cryoglobulinemic glomerulonephritis are the two predominant glomerular pathologies seen in WM. In this article we review the kidney diseases associated with WM. We also briefly review some nephrotoxicities of novel chemotherapeutic and targeted therapies used for the treatment of WM.",

keywords = "MPGN, Waldenstr{\"o}m macroglobulinemia, amyloidosis, onconephrology, paraproteinemia",

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doi = "10.1093/ndt/gfy320",

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T1 - Kidney diseases associated with Waldenström macroglobulinemia

AU - Uppal, Nupur N.

AU - Monga, Divya

AU - Vernace, Melchiore A.

AU - Mehtabdin, Khurram

AU - Shah, Hitesh H.

AU - Bijol, Vanesa

AU - Jhaveri, Kenar D.

PY - 2019/10/1

Y1 - 2019/10/1

N2 - Waldenström macroglobulinemia (WM) is a rare B-cell lymphoma characterized by lymphoplasmacytic cell infiltration in the bone marrow and other organs and the presence of a monoclonal immunoglobulin M protein in the serum. Although uncommon, several kidney diseases have been associated with WM. In addition to kidney diseases related to lymphoplasmacytic lymphoma infiltration, a variety of glomerular and tubular lesions have been described in patients with WM. Immunoglobulin light chain (AL) amyloidosis and cryoglobulinemic glomerulonephritis are the two predominant glomerular pathologies seen in WM. In this article we review the kidney diseases associated with WM. We also briefly review some nephrotoxicities of novel chemotherapeutic and targeted therapies used for the treatment of WM.

AB - Waldenström macroglobulinemia (WM) is a rare B-cell lymphoma characterized by lymphoplasmacytic cell infiltration in the bone marrow and other organs and the presence of a monoclonal immunoglobulin M protein in the serum. Although uncommon, several kidney diseases have been associated with WM. In addition to kidney diseases related to lymphoplasmacytic lymphoma infiltration, a variety of glomerular and tubular lesions have been described in patients with WM. Immunoglobulin light chain (AL) amyloidosis and cryoglobulinemic glomerulonephritis are the two predominant glomerular pathologies seen in WM. In this article we review the kidney diseases associated with WM. We also briefly review some nephrotoxicities of novel chemotherapeutic and targeted therapies used for the treatment of WM.

KW - MPGN

KW - Waldenström macroglobulinemia

KW - amyloidosis

KW - onconephrology

KW - paraproteinemia

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JO - Nephrology Dialysis Transplantation

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ER -

Kidney diseases associated with Waldenström macroglobulinemia

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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