Key concepts in the early immunology of HIV-1 infection

Basile Siewe, Alan Landay

Research output: Contribution to journalReview articlepeer-review

Abstract

Though HIV-1 is a sexually transmitted infection, the gut associated lymphoid tissue (GALT) that houses about 60% of the body's total immune cells is unequivocally the earliest and most important target of HIV-1. In this review we summarize recent data regarding the early events in HIV-1 pathogenesis, with special emphasis on pathogenic effects on the GALT.

Original languageEnglish (US)
Pages (from-to)102-109
Number of pages8
JournalCurrent Infectious Disease Reports
Volume14
Issue number1
DOIs
StatePublished - Feb 2012
Externally publishedYes

Keywords

  • Adaptive immune system
  • African green monkeys
  • AIDS
  • Antibodies
  • B cells
  • Chronic infection
  • Dendritic cells
  • Early/acute infection
  • GALT
  • HIV-1
  • Immune activation
  • Innate immune system
  • Microbial translocation
  • Natural killer cells
  • Peak viremia
  • Rhesus macaques
  • SIV
  • T cells
  • Viral set-point

ASJC Scopus subject areas

  • Infectious Diseases

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